Other formats:
BibTeX
LaTeX
RIS
@misc{838384,
author = {Dwyer, Michael and Guzi, Timothy and Paruch, Kamil and Doll, Ronald and Keertikar, Kartik and Girijavallabhan, Viyyoor},
keywords = {cyclin dependent kinase; inhibitor; pyrazolopyrimidine},
language = {eng},
title = {Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors},
year = {2004}
}
TY - PAT
ID - 838384
AU - Dwyer, Michael - Guzi, Timothy - Paruch, Kamil - Doll, Ronald - Keertikar, Kartik - Girijavallabhan, Viyyoor
PY - 2004
TI - Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors
KW - cyclin dependent kinase
KW - inhibitor
KW - pyrazolopyrimidine
N2 - In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyridine compds. I [R = (un)substiuted-alkyl, -aryl, -heteroaryl, -heteroarylalkyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -alkenyl, -alkynyl, -aryl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, -aryl, -heteroaryl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 7-amino-5-phenylpyrazolo[1,5-a]pyridine (prepn. given) with 3-formylpyridine. I possessed excellent CDK inhibitory properties as demonstrated by the IC50 value for III of 0.078 .mu.M in inhibition of CDK2.
ER -
DWYER, Michael, Timothy GUZI, Kamil PARUCH, Ronald DOLL, Kartik KEERTIKAR and Viyyoor GIRIJAVALLABHAN. \textit{Pyrazolopyridines as Cyclin-Dependent Kinase Inhibitors}. 2004.
|
