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@misc{838389, author = {Dwyer, Michael and Guzi, Timothy and Paruch, Kamil and Doll, Ronald and Keertikar, Kartik and Girijavallabhan, Viyyoor}, keywords = {cyclin dependent kinase; ínhibitors; pyrazolopyridine}, language = {eng}, title = {Imidazopyridines as Cyclin Dependent Kinase Inhibitors}, year = {2004} }
TY - PAT ID - 838389 AU - Dwyer, Michael - Guzi, Timothy - Paruch, Kamil - Doll, Ronald - Keertikar, Kartik - Girijavallabhan, Viyyoor PY - 2004 TI - Imidazopyridines as Cyclin Dependent Kinase Inhibitors KW - cyclin dependent kinase KW - ínhibitors KW - pyrazolopyridine N2 - In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compds. I [R = (un)substituted-alkyl, -aryl, -heteroaryl, -heterocyclyl, etc.; R1 = H, alkyl or aryl; R2 = H, (un)substituted-alkyl, -aryl, arylalkyl, alkenyl, etc.; R3 = H, halo, CF3, (un)substituted-alkyl, -aryl, etc.; R4 = H, halo, CF3, (un)substituted-alkyl, -cycloalkyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was made by condensation of 8-amino-3-bromo-6-phenylimidazopyridine (prepn. given) with 5-formylpyrimidine. In inhibition assays with CDK2, I possessed excellent inhibitory properties, e.g., II possessed an IC50 value of 0.12 uM. ER -
DWYER, Michael, Timothy GUZI, Kamil PARUCH, Ronald DOLL, Kartik KEERTIKAR and Viyyoor GIRIJAVALLABHAN. \textit{Imidazopyridines as Cyclin Dependent Kinase Inhibitors}. 2004.
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