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@misc{838401,
author = {Paruch, Kamil and Guzi, Timothy and Dwyer, Michael and Doll, Ronald and Girivallabhan, Viyyoor and Mallams, Alan},
keywords = {cyclin dependent kinase; inhibitor; imidazopyrazine},
language = {eng},
title = {Imidazopyrazines as Cyclin Dependent Kinase Inhibitors},
year = {2004}
}
TY - PAT
ID - 838401
AU - Paruch, Kamil - Guzi, Timothy - Dwyer, Michael - Doll, Ronald - Girivallabhan, Viyyoor - Mallams, Alan
PY - 2004
TI - Imidazopyrazines as Cyclin Dependent Kinase Inhibitors
KW - cyclin dependent kinase
KW - inhibitor
KW - imidazopyrazine
N2 - In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyrazine compds. of formula I [R = H, halo, (un)substituted-aryl, -heteroaryl, -cycloalkyl, etc.; R1 = H, halo or alkyl; R2 = halo, (un)substituted-alkyl, -aryl, -arylalkyl, etc.; R3 = H, (un)substituted-aryl, -heteroaryl, -heterocyclyl, etc.] as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Thus, e.g., II was prepd. by condensation of 8-chloro-3-methylimidazo[1,2-a]pyrazine with 4-(aminomethyl)pyridine. I possessed excellent CDK inhibitory properties, e.g., II demonstrated an IC50 value of 22.5 uM.
ER -
PARUCH, Kamil, Timothy GUZI, Michael DWYER, Ronald DOLL, Viyyoor GIRIVALLABHAN and Alan MALLAMS. \textit{Imidazopyrazines as Cyclin Dependent Kinase Inhibitors}. 2004.
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