Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay

GRACIA, T., P.D. JONES, E.B. HIGLEY, Klára HILSCHEROVÁ, J. NEWSTED, M.B. MURPHY, A.K.Y. CHAN, X.W. ZHANG, M. HECKER, P.K.S. LAM, R.S.S. WU and J.P. GIESY. Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay. Environmental Science and Pollution Research. Heidelberg: Springer, 2008, vol. 15, No 4, 13 pp. ISSN 0944-1344.

Basic information

• Original name: Modulation of steroidogenesis by coastal waters and sewage effluents of Hong Kong, China, using the H295R assay
• Name in Czech: Modulace steroidogeneze v H295R po expozici vzorků z Hong Kong
• Authors: GRACIA, T. (840 United States of America), P.D. JONES (840 United States of America), E.B. HIGLEY (840 United States of America), Klára HILSCHEROVÁ (203 Czech Republic, guarantor), J. NEWSTED (840 United States of America), M.B. MURPHY (840 United States of America), A.K.Y. CHAN (840 United States of America), X.W. ZHANG (840 United States of America), M. HECKER (840 United States of America), P.K.S. LAM (840 United States of America), R.S.S. WU (840 United States of America) and J.P. GIESY (840 United States of America).
• Edition: Environmental Science and Pollution Research, Heidelberg, Springer, 2008, 0944-1344.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30304 Public and environmental health
• Country of publisher: Germany
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.492
• RIV identification code: RIV/00216224:14310/08:00028087
• Organization unit: Faculty of Science
• UT WoS: 000256910500008
• Keywords (in Czech): H295R; endokrinní disrupce; in vitro
• Keywords in English: H295R; endocrine disruption; in vitro
• Tags: endocrine disruption, H295R, in vitro
• Tags: International impact, Reviewed

Abstract

This complex study investigates modulation of steroidogenesis in model adrenocortical cell line H295R by samples from coastal waters and sewage effluents of Hong Kong. It shows significant modulations of several steroidogenic enzymes by the tested environmental samples.

Abstract (in Czech)

Tato komplexní studie zkoumá ovlivnění steroidogeneze v buněčném modelu z kůry nadledvinek H295R po expozici vzorků povrchových a odpadních vod z oblasti Hong Kongu. Výsledky ukazují významnou modulaci některých klíčových enzymů steroidogeneze po expozici vzorků z prostředí.

Links

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)

• 2B08036, research and development project: Name: Nové molekulárně biologické a biochemické metody pro monitoring estrogenů a dalších chemických endokrinních disruptorů (Acronym: ENVISCREEN)

Investor: Ministry of Education, Youth and Sports of the CR, New molecular biology and biochemical methods to monitor estrogens and other endocrine disruptors in the environment of the C.R.