MOHR, Pavel, Ján PEČEŇÁK, Jaromír ŠVESTKA and T. TREUER. Treatment of acute agitation in psychotic disorders. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2005, vol. 26, No 4, p. 327-335. ISSN 0172-780X.
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Basic information
Original name Treatment of acute agitation in psychotic disorders
Name in Czech Diskuse o léčbě akutního psychotického onemocnění
Authors MOHR, Pavel, Ján PEČEŇÁK, Jaromír ŠVESTKA and T. TREUER.
Edition Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2005, 0172-780X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.005
Organization unit Faculty of Medicine
UT WoS 000233233000013
Keywords in English agitation; schizophreni; second generation antipsychotics; olanzapine; ziprasidone
Tags agitation, olanzapine, schizophreni, second generation antipsychotics, ziprasidone
Changed by Changed by: prof. MUDr. Eva Češková, CSc., učo 726. Changed: 30/6/2009 10:52.
Abstract
Several psychotic disorders, including schizophrenia, may be associated with symptoms of acute agitation and aggression. While drug treatment of agitation is often essential, non-pharmacological interventions, both environmental and behavioral, also play important roles in the complex management of agitated patients. The most extensively used psychotropic drugs are parenteral. formulas of conventional antipsychotics and benzodiazepines. Recently, injection forms of two second generation antipsychotics, olanzapine and ziprasidone, have become available. Both drugs have shown adequate efficacy and tolerability in several double-blind trials of intramuscular administration in acutely agitated psychotic patients. Compared to conventional medication, injection forms of the new antipsychotics may have a faster onset of action and more favorable profile of adverse events. Alternative approaches to injection administration include liquid drug formula, orally disintegrating tablets and wafers, treatment initiation with high doses, or rapid dose escalation. Evidence suggests that second-generation antipsychotics should be among the first-line choices in the treatment of agitation in acute psychosis.
Abstract (in Czech)
Článek popisuje zkušenosti a výstupy z odborných studií, prováděných na psychiatrických klinikách v různých zemích. Nabízí různé pohledy a diskusi
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