A 2009

DNA repair and its quality control

KREJČÍ, Lumír

Basic information

Original name

DNA repair and its quality control

Name in Czech

Kontrola kvality u DNA opravy

Edition

Budapest, Hungary, 2009

Publisher

INSTRUCT

Other information

Language

English

Type of outcome

Audiovizuální tvorba

Field of Study

10600 1.6 Biological sciences

Country of publisher

Hungary

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Medicine

Keywords in English

DNA repair; DNA damage; replication; genomic instability

Tags

International impact
Změněno: 23/4/2010 15:29, doc. Mgr. Lumír Krejčí, Ph.D.

Abstract

V originále

Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.

In Czech

Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.

Links

GA204/02/0027, research and development project
Name: Molekulární analýza struktury a funkce typických a alternativních telomer u rostlin
GA301/09/1917, research and development project
Name: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu
Investor: Czech Science Foundation
LC06030, research and development project
Name: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)
Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment