Detailed Information on Publication Record
2009
DNA repair and its quality control
KREJČÍ, LumírBasic information
Original name
DNA repair and its quality control
Name in Czech
Kontrola kvality u DNA opravy
Authors
Edition
Budapest, Hungary, 2009
Publisher
INSTRUCT
Other information
Language
English
Type of outcome
Audiovizuální tvorba
Field of Study
10600 1.6 Biological sciences
Country of publisher
Hungary
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Organization unit
Faculty of Medicine
Keywords in English
DNA repair; DNA damage; replication; genomic instability
Tags
International impact
Změněno: 23/4/2010 15:29, doc. Mgr. Lumír Krejčí, Ph.D.
V originále
Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.
In Czech
Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination. We find that SUMOylation can significantly influence the biochemical properties of the modified proteins as well as their localization. The precise role of SUMOylation during recombination and DNA repair is still indistinct. Characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52 will be presented and the model for the recombination quality control discussed.
Links
GA204/02/0027, research and development project |
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GA301/09/1917, research and development project |
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LC06030, research and development project |
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MSM0021622413, plan (intention) |
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