Draft genome sequence of the sexually transmitted pathogen
Trichomonas vaginalis

J 2007

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

CARLTON, Jane, R.P. HIRT, J.C. SILVA, A.L. DELCHER, M. SCHATZ et. al.

Basic information

Original name

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Name in Czech

Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis

Authors

CARLTON, Jane (826 United Kingdom of Great Britain and Northern Ireland), R.P. HIRT (756 Switzerland), J.C. SILVA (620 Portugal), A.L. DELCHER (840 United States of America), M. SCHATZ (276 Germany), Q. ZHAO (156 China), J.R. WORTMAN (840 United States of America), S.L. BIDWELL (840 United States of America), U.C. ALSMARK (826 United Kingdom of Great Britain and Northern Ireland), S. BESTEIRO (826 United Kingdom of Great Britain and Northern Ireland), T. SICHERITZ-PONTEN (208 Denmark), C.J. NOEL (250 France), J.B. DACKS (124 Canada), P.G. FOSTER (826 United Kingdom of Great Britain and Northern Ireland), C. SIMILLION (56 Belgium), Y. VAN DE PEER (56 Belgium), D. MIRANDA-SAAVEDRA (826 United Kingdom of Great Britain and Northern Ireland), G.J. BARTON (826 United Kingdom of Great Britain and Northern Ireland), G.D. WESTROP (826 United Kingdom of Great Britain and Northern Ireland), S. MULLER (276 Germany), D. DESSI (380 Italy), P.L. FIORI (380 Italy), Q. REN (840 United States of America), I. PAULSEN (840 United States of America), H. ZHANG (840 United States of America), F.D. BASTIDA-CORCUERA (724 Spain), A. SIMOES-BARBOSA (76 Brazil), M.T. BROWN (840 United States of America), R. HAYES (840 United States of America), M. MUKHERJEE (840 United States of America), C.Y. OKUMURA (840 United States of America), R. SCHNEIDER (840 United States of America), A.J. SMITH (840 United States of America), Štěpánka VAŇÁČOVÁ (203 Czech Republic, guarantor), M. VILLALVAZO (840 United States of America), B.J. HAAS (840 United States of America), M. PERTEA (840 United States of America), T. FELDBLYUM (840 United States of America), T.R. UTTERBACK (840 United States of America), Chung-Li SHU (156 China), K. OSOEGAWA (840 United States of America), P.J. DE JONG (840 United States of America), Ivan HRDY (203 Czech Republic), Lenka HORVATHOVA (203 Czech Republic), Zuzana ZUBACOVA (703 Slovakia), Pavel DOLEZAL (203 Czech Republic), S.B. MALIK (840 United States of America), J.Jr. LOGSDON (840 United States of America), K. HENZE (276 Germany), A. GUPTA (840 United States of America), C.C. WANG (840 United States of America), R.L. DUNNE (840 United States of America), J.A. UPCROFT (36 Australia), Peter UPCROFT (36 Australia), Owen WHITE (840 United States of America), S.L. SALZBERG (840 United States of America), P. TANG (158 Taiwan), Cheng-Hsun CHIU (158 Taiwan), Ying-Shiung LEE (158 Taiwan), T.M. EMBLEY (826 United Kingdom of Great Britain and Northern Ireland), G.H. COOMBS (826 United Kingdom of Great Britain and Northern Ireland), J.C. MOTTRAM (826 United Kingdom of Great Britain and Northern Ireland), Jan TACHEZY (203 Czech Republic), C. FRASER-LIGGETT (840 United States of America) and Patricia J. JOHNSON (840 United States of America)

Edition

Science, 2007, 0036-8075

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 26.372

RIV identification code

RIV/00216224:14310/07:00036232

Organization unit

Faculty of Science

UT WoS

000243407400037

Keywords (in Czech)

Trichomonas; genome; protozoa; transposon elements; hydrogenosome: mitochondria

Keywords in English

Trichomonas; genome; protozoa; transposon elements; hydrogenosome: mitochondria

Abstract

ORIG CZ

V originále

We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.

In Czech

Links

MSM0021622413, plan (intention)

Name: Proteiny v metabolismu a při interakci organismů s prostředím

Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment

Citovat

CARLTON, Jane, R.P. HIRT, J.C. SILVA, A.L. DELCHER, M. SCHATZ, Q. ZHAO, J.R. WORTMAN, S.L. BIDWELL, U.C. ALSMARK, S. BESTEIRO, T. SICHERITZ-PONTEN, C.J. NOEL, J.B. DACKS, P.G. FOSTER, C. SIMILLION, Y. VAN DE PEER, D. MIRANDA-SAAVEDRA, G.J. BARTON, G.D. WESTROP, S. MULLER, D. DESSI, P.L. FIORI, Q. REN, I. PAULSEN, H. ZHANG, F.D. BASTIDA-CORCUERA, A. SIMOES-BARBOSA, M.T. BROWN, R. HAYES, M. MUKHERJEE, C.Y. OKUMURA, R. SCHNEIDER, A.J. SMITH, Štěpánka VAŇÁČOVÁ, M. VILLALVAZO, B.J. HAAS, M. PERTEA, T. FELDBLYUM, T.R. UTTERBACK, Chung-Li SHU, K. OSOEGAWA, P.J. DE JONG, Ivan HRDY, Lenka HORVATHOVA, Zuzana ZUBACOVA, Pavel DOLEZAL, S.B. MALIK, J.Jr. LOGSDON, K. HENZE, A. GUPTA, C.C. WANG, R.L. DUNNE, J.A. UPCROFT, Peter UPCROFT, Owen WHITE, S.L. SALZBERG, P. TANG, Cheng-Hsun CHIU, Ying-Shiung LEE, T.M. EMBLEY, G.H. COOMBS, J.C. MOTTRAM, Jan TACHEZY, C. FRASER-LIGGETT and Patricia J. JOHNSON. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science. 2007, vol. 315, No 5809, p. 207-212. ISSN 0036-8075.

@article{840506,
   author = {Carlton, Jane and Hirt, R.P. and Silva, J.C. and Delcher, A.L. and Schatz, M. and Zhao, Q. and Wortman, J.R. and Bidwell, S.L. and Alsmark, U.C. and Besteiro, S. and SicheritzandPonten, T. and Noel, C.J. and Dacks, J.B. and Foster, P.G. and Simillion, C. and Van de Peer, Y. and MirandaandSaavedra, D. and Barton, G.J. and Westrop, G.D. and Muller, S. and Dessi, D. and Fiori, P.L. and Ren, Q. and Paulsen, I. and Zhang, H. and BastidaandCorcuera, F.D. and SimoesandBarbosa, A. and Brown, M.T. and Hayes, R. and Mukherjee, M. and Okumura, C.Y. and Schneider, R. and Smith, A.J. and Vaňáčová, Štěpánka and Villalvazo, M. and Haas, B.J. and Pertea, M. and Feldblyum, T. and Utterback, T.R. and Shu, ChungandLi and Osoegawa, K. and de Jong, P.J. and Hrdy, Ivan and Horvathova, Lenka and Zubacova, Zuzana and Dolezal, Pavel and Malik, S.B. and Logsdon, J.Jr. and Henze, K. and Gupta, A. and Wang, C.C. and Dunne, R.L. and Upcroft, J.A. and Upcroft, Peter and White, Owen and Salzberg, S.L. and Tang, P. and Chiu, ChengandHsun and Lee, YingandShiung and Embley, T.M. and Coombs, G.H. and Mottram, J.C. and Tachezy, Jan and FraserandLiggett, C. and Johnson, Patricia J.},
   article_number = {5809},
   keywords = {Trichomonas; genome; protozoa; transposon elements; hydrogenosome: mitochondria},
   language = {eng},
   issn = {0036-8075},
   journal = {Science},
   title = {Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis},
   volume = {315},
   year = {2007}
}

TY  - JOUR
ID  - 840506
AU  - Carlton, Jane - Hirt, R.P. - Silva, J.C. - Delcher, A.L. - Schatz, M. - Zhao, Q. - Wortman, J.R. - Bidwell, S.L. - Alsmark, U.C. - Besteiro, S. - Sicheritz-Ponten, T. - Noel, C.J. - Dacks, J.B. - Foster, P.G. - Simillion, C. - Van de Peer, Y. - Miranda-Saavedra, D. - Barton, G.J. - Westrop, G.D. - Muller, S. - Dessi, D. - Fiori, P.L. - Ren, Q. - Paulsen, I. - Zhang, H. - Bastida-Corcuera, F.D. - Simoes-Barbosa, A. - Brown, M.T. - Hayes, R. - Mukherjee, M. - Okumura, C.Y. - Schneider, R. - Smith, A.J. - Vaňáčová, Štěpánka - Villalvazo, M. - Haas, B.J. - Pertea, M. - Feldblyum, T. - Utterback, T.R. - Shu, Chung-Li - Osoegawa, K. - de Jong, P.J. - Hrdy, Ivan - Horvathova, Lenka - Zubacova, Zuzana - Dolezal, Pavel - Malik, S.B. - Logsdon, J.Jr. - Henze, K. - Gupta, A. - Wang, C.C. - Dunne, R.L. - Upcroft, J.A. - Upcroft, Peter - White, Owen - Salzberg, S.L. - Tang, P. - Chiu, Cheng-Hsun - Lee, Ying-Shiung - Embley, T.M. - Coombs, G.H. - Mottram, J.C. - Tachezy, Jan - Fraser-Liggett, C. - Johnson, Patricia J.
PY  - 2007
TI  - Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
JF  - Science
VL  - 315
IS  - 5809
SP  - 207-212
EP  - 207-212
SN  - 00368075
KW  - Trichomonas
KW  - genome
KW  - protozoa
KW  - transposon elements
KW  - hydrogenosome: mitochondria
N2  - We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with the shaping of metabolic pathways that likely transpired through lateral gene transfer from bacteria, and amplification of specific gene families implicated in pathogenesis and phagocytosis of host proteins may exemplify adaptations of the parasite during its transition to a urogenital environment. The genome sequence predicts previously unknown functions for the hydrogenosome, which support a common evolutionary origin of this unusual organelle with mitochondria.
ER  -

CARLTON, Jane, R.P. HIRT, J.C. SILVA, A.L. DELCHER, M. SCHATZ, Q. ZHAO, J.R. WORTMAN, S.L. BIDWELL, U.C. ALSMARK, S. BESTEIRO, T. SICHERITZ-PONTEN, C.J. NOEL, J.B. DACKS, P.G. FOSTER, C. SIMILLION, Y. VAN DE PEER, D. MIRANDA-SAAVEDRA, G.J. BARTON, G.D. WESTROP, S. MULLER, D. DESSI, P.L. FIORI, Q. REN, I. PAULSEN, H. ZHANG, F.D. BASTIDA-CORCUERA, A. SIMOES-BARBOSA, M.T. BROWN, R. HAYES, M. MUKHERJEE, C.Y. OKUMURA, R. SCHNEIDER, A.J. SMITH, Štěpánka VAŇÁČOVÁ, M. VILLALVAZO, B.J. HAAS, M. PERTEA, T. FELDBLYUM, T.R. UTTERBACK, Chung-Li SHU, K. OSOEGAWA, P.J. DE JONG, Ivan HRDY, Lenka HORVATHOVA, Zuzana ZUBACOVA, Pavel DOLEZAL, S.B. MALIK, J.Jr. LOGSDON, K. HENZE, A. GUPTA, C.C. WANG, R.L. DUNNE, J.A. UPCROFT, Peter UPCROFT, Owen WHITE, S.L. SALZBERG, P. TANG, Cheng-Hsun CHIU, Ying-Shiung LEE, T.M. EMBLEY, G.H. COOMBS, J.C. MOTTRAM, Jan TACHEZY, C. FRASER-LIGGETT and Patricia J. JOHNSON. Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. \textit{Science}. 2007, vol.~315, No~5809, p.~207-212. ISSN~0036-8075.

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