Trichomonas vaginalis initiator binding protein, IBP39, contains a novel DNA binding motif

LAU, A.O.T., D.R. LISTON, Štěpánka VAŇÁČOVÁ and Patricia J. JOHNSON. Trichomonas vaginalis initiator binding protein, IBP39, contains a novel DNA binding motif. Molecular and Biochemical Parasitology. ELSEVIER, 2003, vol. 130, No 2, p. 167-171. ISSN 0166-6851.

Basic information

Original name

Trichomonas vaginalis initiator binding protein, IBP39, contains a novel DNA binding motif

Name in Czech

Trichomonas vaginalis initiator binding protein, IBP39, contains a novel DNA binding motif

Authors

LAU, A.O.T. (840 United States of America), D.R. LISTON (840 United States of America), Štěpánka VAŇÁČOVÁ (203 Czech Republic, guarantor) and Patricia J. JOHNSON (840 United States of America)

Edition

Molecular and Biochemical Parasitology, ELSEVIER, 2003, 0166-6851

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Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

Genetics and molecular biology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.882

RIV identification code

RIV/00216224:14310/03:00036236

Organization unit

Faculty of Science

UT WoS

000185273100016

Keywords (in Czech)

Trichomonas; initiator binding protein; transcription; protozoa

Keywords in English

Trichomonas; initiator binding protein; transcription; protozoa

Tags

initiator binding protein, protozoa, Transcription, Trichomonas

Tags

International impact, Reviewed

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Abstract

V originále

This study focuses on the detailed characterization of the only transcription factor identified in the human pathogen Trichomonas vaginalis, the IBP39 protein. Here we show the nuclear localization of IBP39. In addition, we map the DNA binding domain. It resides near the N-terminus of the protein, between amino acids 45 and 71. The residues 66-70 (KMKKK) are critical for DNA binding. This is the first DNA binding domain to be mapped in the only transcription factor in this parasite to date.

In Czech

This study focuses on the detailed characterization of the only transcription factor identified in the human pathogen Trichomonas vaginalis, the IBP39 protein. Here we show the nuclear localization of IBP39. In addition, we map the DNA binding domain. It resides near the N-terminus of the protein, between amino acids 45 and 71. The residues 66-70 (KMKKK) are critical for DNA binding. This is the first DNA binding domain to be mapped in the only transcription factor in this parasite to date.