GRYCOVÁ, Lenka, Roger DOMMISSE, Luc PIETERS and Radek MAREK. NMR determination of pKa values of indoloquinoline alkaloids. Magnetic Resonance in Chemistry. John Wiley & Sons, 2009, vol. 47, No 11, p. 977-981. ISSN 0749-1581. doi:10.1002/mrc.2494.
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Basic information
Original name NMR determination of pKa values of indoloquinoline alkaloids
Name in Czech Stanovení pKa hodnot indolochinolinových alkaloidů pomocí NMR spektroskopie
Authors GRYCOVÁ, Lenka (203 Czech Republic, belonging to the institution), Roger DOMMISSE (56 Belgium), Luc PIETERS (56 Belgium) and Radek MAREK (203 Czech Republic, guarantor, belonging to the institution).
Edition Magnetic Resonance in Chemistry, John Wiley & Sons, 2009, 0749-1581.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10403 Physical chemistry
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW DOI: 10.1002/mrc.2494
Impact factor Impact factor: 1.612
RIV identification code RIV/00216224:14310/09:00036368
Organization unit Faculty of Science
UT WoS 000271123300010
Keywords in English 1H NMR;chemical shift;cryptolepine;isocryptolepine;neocryptolepine;isoneocryptolepine;malaria;pH;determination of pKa
Tags International impact, Reviewed
Changed by Changed by: prof. RNDr. Radek Marek, Ph.D., učo 381. Changed: 17. 6. 2013 14:36.
Malaria is one of the most serious global health problems. Isolating new therapeutic agents with potential antimalarial activity from natural sources or preparing such agents either semisynthetically or synthetically is one strategy for solving the problem of resistance constantly evolving to the drugs currently in use. For alkaloids, the acid-base dissociation constant, pKa, is an important characteristic, thought to be associated with biological activity. In this contribution, pKa values for several indoloquinoline alkaloids were determined by using 1H NMR spectroscopy in a mixture of solvents. The data were recalculated for water solutions using the correction factors reported previously. The structural dependence of the pKa values for cryptolepine and its isomers neocryptolepine, isocryptolepine and isoneocryptolepine as well as some substituted neocryptolepine derivatives is discussed.
Abstract (in Czech)
pKa hodnoty některých indolochinolinových alkaloidů byly stanoveny pomocí 1H NMR spektroskopie.
LC06030, research and development projectName: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment
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