Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells

NAVRÁTILOVÁ, Jarmila, Pavla JUNGOVÁ, Petr VAŇHARA, Jan PREISLER, Viktor KANICKÝ and Jan ŠMARDA. Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells. International Journal of Molecular Medicine. Greece: Lychnia, Athens, Greece, 2009, vol. 24, No 5, p. 661-670. ISSN 1107-3756.

Basic information

• Original name: Copper ions regulate cytotoxicity of disulfiram to myeloid leukemia cells
• Name in Czech: Cytotoxicitu disulfiramu vůči buňkám myeloidní leukémie ovlivňují měďnaté ionty
• Authors: NAVRÁTILOVÁ, Jarmila (203 Czech Republic, belonging to the institution), Pavla JUNGOVÁ (203 Czech Republic, belonging to the institution), Petr VAŇHARA (203 Czech Republic, belonging to the institution), Jan PREISLER (203 Czech Republic, belonging to the institution), Viktor KANICKÝ (203 Czech Republic, belonging to the institution) and Jan ŠMARDA (203 Czech Republic, guarantor).
• Edition: International Journal of Molecular Medicine, Greece, Lychnia, Athens, Greece, 2009, 1107-3756.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: Greece
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 1.980
• RIV identification code: RIV/00216224:14310/09:00029462
• Organization unit: Faculty of Science
• UT WoS: 000270497400009
• Keywords (in Czech): disulfiram; měď; myeloidní leukémie; buněčná hustota; efekt inokula; SALD ICP MS
• Keywords in English: disulfiram; copper; myeloid leukemia; cell density; inoculum effect; SALD ICP MS
• Tags: International impact, Reviewed

Abstract

In this study, we report the cell density-dependent induction of apoptosis of human acute myeloid leukemia U937 and ML-1 cells by disulfiram (DSF), the dithiocarbamate drug recently proposed for treatment of human cancers. This effect is dependent on uptake of extracellular copper and its intracellular accumulation.

Abstract (in Czech)

V této práci popisujeme indukci apoptózy lidských buněk akutní myeloidní leukémie U937 a ML-1, která je závislá na buněčné hustotě, prostřednictvím disulfiramu. Tento účinek závisí na příjmu extracelulární mědi a jejím hromadění uvnitř buněk.

Links

• GA203/09/1025, research and development project: Name: Multidetekční platforma pro mikrokolonové separace proteinů a peptidů

Investor: Czech Science Foundation, Multidetection platform for microcolumn separation of proteins and peptides

• GA301/09/1115, research and development project: Name: Úloha proteinů c-Myb a Cox-2 při tvorbě střevních nádorů

Investor: Czech Science Foundation, The role of c-Myb and Cox-2 proteins in colon carcinogenesis

• MSM0021622411, plan (intention): Name: Studium a aplikace plazmochemických reakcí v neizotermickém nízkoteplotním plazmatu a jeho interakcí s povrchem pevných látek

Investor: Ministry of Education, Youth and Sports of the CR, Study and application of plasma chemical reactions in non-isothermic low temperature plasma and its interaction with solid surface

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)

• MSM0021622415, plan (intention): Name: Molekulární podstata buněčných a tkáňových regulací

Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations