| MATĚJKOVÁ POSPÍŠILOVÁ, Petra, Magdalena FLASAROVÁ, Hana ZÁKOUCKÁ, Milan BOŘEK, Soňa KŘEMENOVÁ, Petr ARENBERGER, Vladana WOZNICOVÁ, G.M. WEINSTOCK and David ŠMAJS. Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. Journal of Medical Microbiology. SOC GENERAL MICROBIOLOGY, 2009, vol. 58, No 6, p. 832–836. ISSN 0022-2615. |
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@article{844664,
author = {Matějková Pospíšilová, Petra and Flasarová, Magdalena and Zákoucká, Hana and Bořek, Milan and Křemenová, Soňa and Arenberger, Petr and Woznicová, Vladana and Weinstock, G.M. and Šmajs, David},
article_number = {6},
keywords = {penicillin-G benzathine; azithromycin resistance; clinical specimens; isolate; PCR},
language = {eng},
issn = {0022-2615},
journal = {Journal of Medical Microbiology},
title = {Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum.},
url = {http://jmm.sgmjournals.org/cgi/reprint/58/6/832?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Matejkova&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT},
volume = {58},
year = {2009}
}
TY - JOUR
ID - 844664
AU - Matějková Pospíšilová, Petra - Flasarová, Magdalena - Zákoucká, Hana - Bořek, Milan - Křemenová, Soňa - Arenberger, Petr - Woznicová, Vladana - Weinstock, G.M. - Šmajs, David
PY - 2009
TI - Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum.
JF - Journal of Medical Microbiology
VL - 58
IS - 6
SP - 832–836
EP - 832–836
PB - SOC GENERAL MICROBIOLOGY
SN - 00222615
KW - penicillin-G benzathine
KW - azithromycin resistance
KW - clinical specimens
KW - isolate
KW - PCR
UR - http://jmm.sgmjournals.org/cgi/reprint/58/6/832?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Matejkova&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT
N2 - We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively.
ER -
MATĚJKOVÁ POSPÍŠILOVÁ, Petra, Magdalena FLASAROVÁ, Hana ZÁKOUCKÁ, Milan BOŘEK, Soňa KŘEMENOVÁ, Petr ARENBERGER, Vladana WOZNICOVÁ, G.M. WEINSTOCK and David ŠMAJS. Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. \textit{Journal of Medical Microbiology}. SOC GENERAL MICROBIOLOGY, 2009, vol.~58, No~6, p.~832–836. ISSN~0022-2615.
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