MATĚJKOVÁ POSPÍŠILOVÁ, Petra, Magdalena FLASAROVÁ, Hana ZÁKOUCKÁ, Milan BOŘEK, Soňa KŘEMENOVÁ, Petr ARENBERGER, Vladana WOZNICOVÁ, G.M. WEINSTOCK and David ŠMAJS. Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. Journal of Medical Microbiology. SOC GENERAL MICROBIOLOGY, 2009, vol. 58, No 6, p. 832–836. ISSN 0022-2615. |
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@article{844664, author = {Matějková Pospíšilová, Petra and Flasarová, Magdalena and Zákoucká, Hana and Bořek, Milan and Křemenová, Soňa and Arenberger, Petr and Woznicová, Vladana and Weinstock, G.M. and Šmajs, David}, article_number = {6}, keywords = {penicillin-G benzathine; azithromycin resistance; clinical specimens; isolate; PCR}, language = {eng}, issn = {0022-2615}, journal = {Journal of Medical Microbiology}, title = {Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum.}, url = {http://jmm.sgmjournals.org/cgi/reprint/58/6/832?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Matejkova&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT}, volume = {58}, year = {2009} }
TY - JOUR ID - 844664 AU - Matějková Pospíšilová, Petra - Flasarová, Magdalena - Zákoucká, Hana - Bořek, Milan - Křemenová, Soňa - Arenberger, Petr - Woznicová, Vladana - Weinstock, G.M. - Šmajs, David PY - 2009 TI - Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. JF - Journal of Medical Microbiology VL - 58 IS - 6 SP - 832–836 EP - 832–836 PB - SOC GENERAL MICROBIOLOGY SN - 00222615 KW - penicillin-G benzathine KW - azithromycin resistance KW - clinical specimens KW - isolate KW - PCR UR - http://jmm.sgmjournals.org/cgi/reprint/58/6/832?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Matejkova&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT N2 - We report an occurrence of treatment failure after oral spiramycin therapy in a man with secondary syphilis and a reported penicillin and tetracycline allergy. Molecular detection revealed treponemal DNA in the blood of the patient and sequencing of the 23S rDNA identified an A to G transition at the gene position corresponding to position 2059 in the Escherichia coli 23S rRNA gene. The occurrence of this novel 23S rDNA mutation was examined among 7 rabbit-propagated syphilitic strains of Treponema pallidum and among 22 syphilis patient isolates from the Czech Republic. The prevalence of A2058G and A2059G mutations among clinical specimens was 18.2 and 18.2 %, respectively. ER -
MATĚJKOVÁ POSPÍŠILOVÁ, Petra, Magdalena FLASAROVÁ, Hana ZÁKOUCKÁ, Milan BOŘEK, Soňa KŘEMENOVÁ, Petr ARENBERGER, Vladana WOZNICOVÁ, G.M. WEINSTOCK and David ŠMAJS. Macrolide treatment failure in a case of secondary syphilis: a novel A2059G mutation in the 23S rRNA gene of Treponema pallidum subsp. pallidum. \textit{Journal of Medical Microbiology}. SOC GENERAL MICROBIOLOGY, 2009, vol.~58, No~6, p.~832–836. ISSN~0022-2615.
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