Genetic variants of the Endocannabinnoid receptor type I (CNR1)
gene: association with susceptibility to cutaneous T-cell
lymphoma

D 2009

Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Petr BIENERT and Anna VAŠKŮ

Basic information

Original name

Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma

Name in Czech

Genetické polymorfismy v genu pro endokanabinoidní receptor typu I (CNR1): asociace s vnímavostí vůči kožnímu T-lymfomu

Authors

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Petr BIENERT and Anna VAŠKŮ

Edition

2009. vyd. USA, Journal of Investigative Dermatology, p. S51-51, 1 pp. 2009

Publisher

Nature Publishing Group, Macmillan Publishers Ltd

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30216 Dermatology and venereal diseases

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 5.543

Organization unit

Faculty of Medicine

ISSN

Keywords (in Czech)

kožní T-lymfom; endokanabinoidy; SNP; asociační studie

Keywords in English

T cell lymphoma; endocannabinoids; SNP; association study

Abstract

ORIG CZ

V originále

Endocannabinoids are lipid mediators thought to modulate central and peripheral neural functions. Recently, the overexpressionof the central and peripheral cannabinoid receptors CB1 and CB2 was reported in various types of lymphomas. Therefore, the aim of the study was to investigate possible associations of 3 common SNPs in CNR1 gene (rs1049343, rs12720071 and rs806368) with cutaneous T-cell lymphoma. The total of 97 patients with CTCL were recruited for the study along with 258 healthy Czech individuals of similar age and gender distribution. No significant differences in genotype distributions as well as allele frequencies were observed between the CTCL cases and controls. Five common haplotypes in the CNR1 gene were identified, whereas the frequencies of the haplotypes differed significantly betweent the cases and the controls (Phap less than 0.001). In the multivariate modelling, the CNR1 4895 C/T (rs806368) expressed an independent prediction role for the CTCL staging (beta = -0.27, P = 0.05). Based on our results, the CNR1 gene could be considered a susceptibility marker for cutaneous T-cell lymphoma.

In Czech

Endokanabinoidy jsou mediátory lipidové povahy, které jsou považovány za významné modulátory centrálních i periferních nervových funkcí. Na základě výsledků této studie se domníváme, že CNR1 gen může být považován za gen vnímavosti pro kožní T-lymfom.

Citovat

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Petr BIENERT and Anna VAŠKŮ. Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma. In Journal of Investigative Dermatology. 2009th ed. USA: Nature Publishing Group, Macmillan Publishers Ltd, 2009, p. S51-51, 1 pp. ISSN 0022-202X.

@inproceedings{845546,
   author = {Vašků, Vladimír and Bienertová Vašků, Julie and Bienert, Petr and Vašků, Anna},
   address = {USA},
   booktitle = {Journal of Investigative Dermatology},
   edition = {2009},
   keywords = {T cell lymphoma; endocannabinoids; SNP; association study},
   language = {eng},
   location = {USA},
   pages = {S51-51},
   publisher = {Nature Publishing Group, Macmillan Publishers Ltd},
   title = {Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma},
   year = {2009}
}

TY  - JOUR
ID  - 845546
AU  - Vašků, Vladimír - Bienertová Vašků, Julie - Bienert, Petr - Vašků, Anna
PY  - 2009
TI  - Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma
PB  - Nature Publishing Group, Macmillan Publishers Ltd
CY  - USA
KW  - T cell lymphoma
KW  - endocannabinoids
KW  - SNP
KW  - association study
N2  - Endocannabinoids are lipid mediators thought to modulate central and peripheral neural functions. Recently, the overexpressionof the central and peripheral cannabinoid receptors CB1 and CB2 was reported in various types of lymphomas. Therefore, the aim of the study was to investigate possible associations of 3 common SNPs in CNR1 gene (rs1049343, rs12720071 and rs806368) with cutaneous T-cell lymphoma. The total of 97 patients with CTCL were recruited for the study along with 258 healthy Czech individuals of similar age and gender distribution. No significant differences in genotype distributions as well as allele frequencies were observed between the CTCL cases and controls. Five common haplotypes in the CNR1 gene were identified, whereas the frequencies of the haplotypes differed significantly betweent the cases and the controls (Phap less than 0.001). In the multivariate modelling, the CNR1 4895 C/T (rs806368) expressed an independent prediction role for the CTCL staging (beta = -0.27, P = 0.05). Based on our results, the CNR1 gene could be considered a susceptibility marker for cutaneous T-cell lymphoma.
ER  -

VAŠKŮ, Vladimír, Julie BIENERTOVÁ VAŠKŮ, Petr BIENERT and Anna VAŠKŮ. Genetic variants of the Endocannabinnoid receptor type I (CNR1) gene: association with susceptibility to cutaneous T-cell lymphoma. In \textit{Journal of Investigative Dermatology}. 2009th ed. USA: Nature Publishing Group, Macmillan Publishers Ltd, 2009, p.~S51-51, 1 pp. ISSN~0022-202X.

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