FALK, Martin, Emilie LUKÁŠOVÁ, Barbora GABRIELOVÁ, Vladan ONDŘEJ and Stanislav KOZUBEK. Chromatin dynamics during DSB repair. Biochimica et Biophysica Acta, Molecular Cell Research. Amsterdam: Elsevier, 2007, vol. 1773, No 10, p. 1534-1545. ISSN 0167-4889. |
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@article{848199, author = {Falk, Martin and Lukášová, Emilie and Gabrielová, Barbora and Ondřej, Vladan and Kozubek, Stanislav}, article_location = {Amsterdam}, article_number = {10}, keywords = {chromatin structure; DNA damage; double-strand breaks (DSB); DNA repair; exchange aberration; genomic instability}, language = {eng}, issn = {0167-4889}, journal = {Biochimica et Biophysica Acta, Molecular Cell Research}, title = {Chromatin dynamics during DSB repair}, volume = {1773}, year = {2007} }
TY - JOUR ID - 848199 AU - Falk, Martin - Lukášová, Emilie - Gabrielová, Barbora - Ondřej, Vladan - Kozubek, Stanislav PY - 2007 TI - Chromatin dynamics during DSB repair JF - Biochimica et Biophysica Acta, Molecular Cell Research VL - 1773 IS - 10 SP - 1534-1545 EP - 1534-1545 PB - Elsevier SN - 01674889 KW - chromatin structure KW - DNA damage KW - double-strand breaks (DSB) KW - DNA repair KW - exchange aberration KW - genomic instability N2 - We show that double strand breaks (DSBs) induced in chromatin of low as well as high density by exposure of human cells to gama-rays are repaired in low-density chromatin. Only slight movement of sporadic DSB loci for short distances was noticed in living cells associated with chromatin decondensation around DSBs. This frequently resulted in their protrusion into the low-density chromatin domains. In these regions, the clustering (contact or fusion) of DSB foci was seen in vivo, and in situ after cell fixation. We propose that the repair of DSB in clustered foci might lead to misjoining of ends and, consequently, to exchange aberrations. ER -
FALK, Martin, Emilie LUKÁŠOVÁ, Barbora GABRIELOVÁ, Vladan ONDŘEJ and Stanislav KOZUBEK. Chromatin dynamics during DSB repair. \textit{Biochimica et Biophysica Acta, Molecular Cell Research}. Amsterdam: Elsevier, 2007, vol.~1773, No~10, p.~1534-1545. ISSN~0167-4889.
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