| FALK, Martin, Emilie LUKÁŠOVÁ, Barbora GABRIELOVÁ, Vladan ONDŘEJ and Stanislav KOZUBEK. Chromatin dynamics during DSB repair. Biochimica et Biophysica Acta, Molecular Cell Research. Amsterdam: Elsevier, 2007, vol. 1773, No 10, p. 1534-1545. ISSN 0167-4889. |
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@article{848199,
author = {Falk, Martin and Lukášová, Emilie and Gabrielová, Barbora and Ondřej, Vladan and Kozubek, Stanislav},
article_location = {Amsterdam},
article_number = {10},
keywords = {chromatin structure; DNA damage; double-strand breaks (DSB); DNA repair; exchange aberration; genomic instability},
language = {eng},
issn = {0167-4889},
journal = {Biochimica et Biophysica Acta, Molecular Cell Research},
title = {Chromatin dynamics during DSB repair},
volume = {1773},
year = {2007}
}
TY - JOUR
ID - 848199
AU - Falk, Martin - Lukášová, Emilie - Gabrielová, Barbora - Ondřej, Vladan - Kozubek, Stanislav
PY - 2007
TI - Chromatin dynamics during DSB repair
JF - Biochimica et Biophysica Acta, Molecular Cell Research
VL - 1773
IS - 10
SP - 1534-1545
EP - 1534-1545
PB - Elsevier
SN - 01674889
KW - chromatin structure
KW - DNA damage
KW - double-strand breaks (DSB)
KW - DNA repair
KW - exchange aberration
KW - genomic instability
N2 - We show that double strand breaks (DSBs) induced in chromatin of low as well as high density by exposure of human cells to gama-rays are repaired in low-density chromatin. Only slight movement of sporadic DSB loci for short distances was noticed in living cells associated with chromatin decondensation around DSBs. This frequently resulted in their protrusion into the low-density chromatin domains. In these regions, the clustering (contact or fusion) of DSB foci was seen in vivo, and in situ after cell fixation. We propose that the repair of DSB in clustered foci might lead to misjoining of ends and, consequently, to exchange aberrations.
ER -
FALK, Martin, Emilie LUKÁŠOVÁ, Barbora GABRIELOVÁ, Vladan ONDŘEJ and Stanislav KOZUBEK. Chromatin dynamics during DSB repair. \textit{Biochimica et Biophysica Acta, Molecular Cell Research}. Amsterdam: Elsevier, 2007, vol.~1773, No~10, p.~1534-1545. ISSN~0167-4889.
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