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@article{848213, author = {Falk, Martin and Lukášová, Emilie and Gabrielová, Barbora and Ondřej, Vladan and Kozubek, Stanislav}, article_location = {BRISTOL}, article_number = {101}, keywords = {DOUBLE-STRAND BREAKS; HIGH-RESOLUTION CYTOMETRY; DNA-DAMAGE; CHROMOSOME DOMAINS; ACTIVE GENES; NUCLEI; SITES; PROTEINS; CELLS; TRANSCRIPTION}, language = {eng}, issn = {1742-6588}, journal = {JOURNAL OF PHYSICS CONFERENCE SERIES}, title = {Local changes of higher-order chromatin structure during DSB-repair}, volume = {-}, year = {2008} }
TY - JOUR ID - 848213 AU - Falk, Martin - Lukášová, Emilie - Gabrielová, Barbora - Ondřej, Vladan - Kozubek, Stanislav PY - 2008 TI - Local changes of higher-order chromatin structure during DSB-repair JF - JOURNAL OF PHYSICS CONFERENCE SERIES VL - - IS - 101 SP - 12018 EP - 12018 PB - IOP PUBLISHING LTD, England SN - 17426588 KW - DOUBLE-STRAND BREAKS KW - HIGH-RESOLUTION CYTOMETRY KW - DNA-DAMAGE KW - CHROMOSOME DOMAINS KW - ACTIVE GENES KW - NUCLEI KW - SITES KW - PROTEINS KW - CELLS KW - TRANSCRIPTION N2 - We show that double-strand breaks (DSBs) induced in DNA of human cells by gamma-radiation arise mainly in active, gene-rich, decondensed chromatin. We demonstrate that DSBs show limited movement in living cells, occasionally resulting in their permanent clustering, which poses a risk of incorrect DNA rejoining. In addition, some DSBs remain unrepaired for several days after irradiation, forming lesions repairable only with difficulty which are hazardous for genome stability. These late DSBs colocalize with heterochromatin markers (dimethylated histone H3 at lysine 9, HP1 and CENP-A proteins), despite the low density of the surrounding chromatin. This indicates that there is epigenetic silencing of loci close to unrepaired DSBs and/or stabilization of damaged decondensed chromatin loops during repair and post-repair reconstitution of chromatin structure. ER -
FALK, Martin, Emilie LUKÁŠOVÁ, Barbora GABRIELOVÁ, Vladan ONDŘEJ a Stanislav KOZUBEK. Local changes of higher-order chromatin structure during DSB-repair. \textit{JOURNAL OF PHYSICS CONFERENCE SERIES}. BRISTOL: IOP PUBLISHING LTD, England, 2008, -, č.~101, s.~12018-12035. ISSN~1742-6588.
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