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@article{851199,
author = {Meluzín, Jaroslav and Vlašín, Michal and Groch, Ladislav and Mayer, Jiří and Křen, Leoš and Raušer, Petr and Tichý, Boris and Horňáček, Ivan and Klabusay, Martin and Kořístek, Zdeněk and Doubek, Michael and Pospíšilová, Šárka and Dušek, Ladislav and Sitar, Jan and Palša, Stanislav and Lexmaulová, Leona},
article_number = {2},
doi = {http://dx.doi.org/10.1159/000141462},
keywords = {Myocardial infarction; Bone marrow cells; Delivery technique},
language = {eng},
issn = {0008-6312},
journal = {Cardiology},
title = {Intracoronary delivery of bone marrow cells to the acutely infarcted myocardium},
volume = {112},
year = {2009}
}
TY - JOUR
ID - 851199
AU - Meluzín, Jaroslav - Vlašín, Michal - Groch, Ladislav - Mayer, Jiří - Křen, Leoš - Raušer, Petr - Tichý, Boris - Horňáček, Ivan - Klabusay, Martin - Kořístek, Zdeněk - Doubek, Michael - Pospíšilová, Šárka - Dušek, Ladislav - Sitar, Jan - Palša, Stanislav - Lexmaulová, Leona
PY - 2009
TI - Intracoronary delivery of bone marrow cells to the acutely infarcted myocardium
JF - Cardiology
VL - 112
IS - 2
SP - 98-106
EP - 98-106
SN - 00086312
KW - Myocardial infarction
KW - Bone marrow cells
KW - Delivery technique
N2 - Objectives: Intracoronary cell transplantation during catheter balloon inflations may be associated with adverse events. We studied the effectiveness of an alternative transplantation technique-intracoronary cell infusion. Methods: Fourteen pigs, which had survived acute myocardial infarction, were randomized into 2 treatment groups and 2 controls. Three days after infarction, 12 pigs underwent allogeneic intracoronary mononuclear bone marrow cell transplantation using either the standard technique (short-term cell injections during repeat balloon inflations, technique A, n = 6) or continuous intracoronary cell infusion without balloon inflations (technique B, n = 6). Implanted cells were stained with fluorescent dye. After transplantation, the pigs were euthanized and myocardial samples were analyzed by fluorescent microscopy. Results: The mean numbers of fluorescently labeled bone marrow cells in the infarction border zone, in the infarction mid-area and in the center of myocardial infarction were 84, 72 and 55 using technique A, and 29, 57 and 46 using technique B, respectively. The mean cell retention in the infarction border zone of 84 cells for technique A and 29 cells for technique B differed significantly (p = 0.034, two-tailed t test). Conclusion: The continuous intracoronary cell infusion technique is a less efficient cell delivery technique as compared with the standard technique using repeat intracoronary balloon inflations.
ER -
MELUZÍN, Jaroslav, Michal VLAŠÍN, Ladislav GROCH, Jiří MAYER, Leoš KŘEN, Petr RAUŠER, Boris TICHÝ, Ivan HORŇÁČEK, Martin KLABUSAY, Zdeněk KOŘÍSTEK, Michael DOUBEK, Šárka POSPÍŠILOVÁ, Ladislav DUŠEK, Jan SITAR, Stanislav PALŠA and Leona LEXMAULOVÁ. Intracoronary delivery of bone marrow cells to the acutely infarcted myocardium. \textit{Cardiology}. 2009, vol.~112, No~2, p.~98-106. ISSN~0008-6312. Available from: https://dx.doi.org/10.1159/000141462.
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