Detailed Information on Publication Record
2009
Intracoronary delivery of bone marrow cells to the acutely infarcted myocardium
MELUZÍN, Jaroslav, Michal VLAŠÍN, Ladislav GROCH, Jiří MAYER, Leoš KŘEN et. al.Basic information
Original name
Intracoronary delivery of bone marrow cells to the acutely infarcted myocardium
Name in Czech
Intrakoronární podání buněk kostní dřeně u akutního infarktu myokardu
Authors
MELUZÍN, Jaroslav (203 Czech Republic, guarantor, belonging to the institution), Michal VLAŠÍN (203 Czech Republic), Ladislav GROCH (203 Czech Republic, belonging to the institution), Jiří MAYER (203 Czech Republic, belonging to the institution), Leoš KŘEN (203 Czech Republic, belonging to the institution), Petr RAUŠER (203 Czech Republic), Boris TICHÝ (203 Czech Republic, belonging to the institution), Ivan HORŇÁČEK (203 Czech Republic), Martin KLABUSAY (203 Czech Republic, belonging to the institution), Zdeněk KOŘÍSTEK (203 Czech Republic, belonging to the institution), Michael DOUBEK (203 Czech Republic, belonging to the institution), Šárka POSPÍŠILOVÁ (203 Czech Republic, belonging to the institution), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Jan SITAR (203 Czech Republic, belonging to the institution), Stanislav PALŠA (203 Czech Republic, belonging to the institution) and Leona LEXMAULOVÁ (203 Czech Republic)
Edition
Cardiology, 2009, 0008-6312
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30201 Cardiac and Cardiovascular systems
Country of publisher
Switzerland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.637
RIV identification code
RIV/00216224:14110/09:00067142
Organization unit
Faculty of Medicine
UT WoS
000260892300003
Keywords in English
Myocardial infarction; Bone marrow cells; Delivery technique
Tags
International impact, Reviewed
Změněno: 29/4/2014 10:06, Ing. Mgr. Věra Pospíšilíková
V originále
Objectives: Intracoronary cell transplantation during catheter balloon inflations may be associated with adverse events. We studied the effectiveness of an alternative transplantation technique-intracoronary cell infusion. Methods: Fourteen pigs, which had survived acute myocardial infarction, were randomized into 2 treatment groups and 2 controls. Three days after infarction, 12 pigs underwent allogeneic intracoronary mononuclear bone marrow cell transplantation using either the standard technique (short-term cell injections during repeat balloon inflations, technique A, n = 6) or continuous intracoronary cell infusion without balloon inflations (technique B, n = 6). Implanted cells were stained with fluorescent dye. After transplantation, the pigs were euthanized and myocardial samples were analyzed by fluorescent microscopy. Results: The mean numbers of fluorescently labeled bone marrow cells in the infarction border zone, in the infarction mid-area and in the center of myocardial infarction were 84, 72 and 55 using technique A, and 29, 57 and 46 using technique B, respectively. The mean cell retention in the infarction border zone of 84 cells for technique A and 29 cells for technique B differed significantly (p = 0.034, two-tailed t test). Conclusion: The continuous intracoronary cell infusion technique is a less efficient cell delivery technique as compared with the standard technique using repeat intracoronary balloon inflations.
In Czech
Continuální intrakoronární podání buněk kostní dřeně je méně účinné než použití standardní techniky využívající opakováné inflace katetrizačního balonku.
Links
| MSM0021622402, plan (intention) |
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| MSM0021622430, plan (intention) |
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