HANÁK, Libor, Ondřej SLABÝ, Ludmila LAUEROVÁ, Leoš KŘEN, Rudolf NENUTIL and Jaroslav MICHÁLEK. Expression pattern of HLA class I antigens in renal cell carsinoma and primary cell line cultures: Methodological implications for immunotherapy. Medical Science Monitor (International Medical Journal of Experimental and Clinical Research). USA: International Scientific Literature, Inc, 2009, vol. 15, No 12, p. CR638-CR643, 6 pp. ISSN 1234-1010.
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Basic information
Original name Expression pattern of HLA class I antigens in renal cell carsinoma and primary cell line cultures: Methodological implications for immunotherapy
Name in Czech Expresní profil HLA antigenů I třídy u renálního karcinomu a primárních buněčých linií: metodologický význam v imunoterapii
Authors HANÁK, Libor (203 Czech Republic), Ondřej SLABÝ (203 Czech Republic), Ludmila LAUEROVÁ (203 Czech Republic), Leoš KŘEN (203 Czech Republic), Rudolf NENUTIL (203 Czech Republic) and Jaroslav MICHÁLEK (203 Czech Republic, guarantor).
Edition Medical Science Monitor (International Medical Journal of Experimental and Clinical Research), USA, International Scientific Literature, Inc, 2009, 1234-1010.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.543
RIV identification code RIV/00216224:14110/09:00036993
Organization unit Faculty of Medicine
UT WoS 000273120300013
Keywords (in Czech) renální karcinom; imunoterapie; HLA antigeny
Keywords in English renal carcinoma; immunotherapy; HLA antigens
Changed by Changed by: Mgr. Anna Potáčová, Ph.D., učo 44190. Changed: 10/12/2009 13:09.
Abstract
In this study both classic and non-classic HLA cals I antigens were tested in tumor specimens and estabilished primary cell cultures derived from renal cell carcinoma patients. Our findings suggest that primary cell line cultures derived from surgical specimens of renal cell carcinomas are a feasible model for immunotherapy research through their high cultivation protential.
Abstract (in Czech)
V této studii byly studovány HLA antigeny na primárních nádorových kulturách získaných od pacientů s renálním karcinomem. Bylo zjištěno, že tyto kultury jsou vhodné pro další imunoterapeutický výzkum, díky jejich vysokému kultvačnímu potenciálu.
Links
2B06058, research and development projectName: Bezpečná biotechnologie alotransplantovaných hematopoetických kmenových buněk u vybraných solidních a hematologických nádorů jako adoptivní imunoterapie (Acronym: NPVII11001)
Investor: Ministry of Education, Youth and Sports of the CR
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