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@article{853983,
author = {Šulák, Ondřej and Cioci, Gianluca and Delia, Monia and Lahmann, Martina and Varrot, Annabelle and Imberty, Anne and Wimmerová, Michaela},
article_location = {CAMBRIDGE},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.str.2009.10.021},
keywords = {lectin; Burkholderia cenocepacia; pathogen; TNF},
language = {eng},
issn = {0969-2126},
journal = {Structure},
title = {A TNF-like Trimeric Lectin Domain from Burkholderia cenocepacia with Specificity for Fucosylated Human Histo-Blood Group Antigens},
url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20152153},
volume = {18},
year = {2010}
}
TY - JOUR
ID - 853983
AU - Šulák, Ondřej - Cioci, Gianluca - Delia, Monia - Lahmann, Martina - Varrot, Annabelle - Imberty, Anne - Wimmerová, Michaela
PY - 2010
TI - A TNF-like Trimeric Lectin Domain from Burkholderia cenocepacia with Specificity for Fucosylated Human Histo-Blood Group Antigens
JF - Structure
VL - 18
IS - 1
SP - 59-72
EP - 59-72
PB - CELL PRESS
SN - 09692126
KW - lectin
KW - Burkholderia cenocepacia
KW - pathogen
KW - TNF
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=20152153
N2 - The opportunistic pathogen Burkholderia cenocepacia expresses several soluble lectins, among them BC2L-C. This lectin exhibits two domains: a C-terminal domain with high sequence similarity to the recently described calcium-dependent mannose-binding lectin BC2L-A, and an N-terminal domain of 156 amino acids without similarity to any known protein. The recombinant N-terminal BC2L-C domain is a new lectin with specificity for fucosylated human histo-blood group epitopes H-type 1, Lewis b, and Lewis Y, as determined by glycan array and isothermal titration calorimetry. Methylselenofucoside was used as ligand to solve the crystal structure of the N-terminal BC2L-C domain. Additional molecular modeling studies rationalized the preference for Lewis epitopes. The structure reveals a trimeric jellyroll arrangement with striking similarity to TNF-like proteins, and to BclA, the spore protein from Bacillus anthracis which may play an important role in bioadhesion of anthrax spores in human lungs.
ER -
ŠULÁK, Ondřej, Gianluca CIOCI, Monia DELIA, Martina LAHMANN, Annabelle VARROT, Anne IMBERTY and Michaela WIMMEROVÁ. A TNF-like Trimeric Lectin Domain from Burkholderia cenocepacia with Specificity for Fucosylated Human Histo-Blood Group Antigens. \textit{Structure}. CAMBRIDGE: CELL PRESS, 2010, vol.~18, No~1, p.~59-72. ISSN~0969-2126. Available from: https://dx.doi.org/10.1016/j.str.2009.10.021.
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