Laser-ablation based spectrochemical analytical methods could be used in applications in which the capability for spatially resolved analysis is required. Such analysis gives a 2-D or 3-D map of the monitored chemical elements. Here we introduce automation of a 2-D surface analysis in the laser-induced breakdown spectroscopy setup by implementation of an autofocus algorithm based on the evaluation of the image sharpness. The most suitable algorithm with respect to its speed, accuracy, and durability against digital noise is chosen by testing different gradient-based methods and methods working in the frequency domain.