TARABOVÁ, Bohumila, Marie NOVÁKOVÁ and Ľubica LACINOVÁ. Haloperidol moderately inhibits cardiovascular L-type calcium current. General Physiology and Biophysics. Bratislava: Slovak Academy of Sciences, 2009, vol. 28, No 3, p. 249-259. ISSN 0231-5882.
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Basic information
Original name Haloperidol moderately inhibits cardiovascular L-type calcium current
Name in Czech Haloperidol mírně inhibuje kardiovaskulární L-typ vápníkového proudu
Authors TARABOVÁ, Bohumila (703 Slovakia), Marie NOVÁKOVÁ (203 Czech Republic, guarantor) and Ľubica LACINOVÁ (703 Slovakia).
Edition General Physiology and Biophysics, Bratislava, Slovak Academy of Sciences, 2009, 0231-5882.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Slovakia
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.741
RIV identification code RIV/00216224:14110/09:00037292
Organization unit Faculty of Medicine
UT WoS 000272335700005
Keywords (in Czech) Haloperidol;kardiomyocyty;akční potenciál;L-typ vápníkového proudu
Keywords in English Haloperidol;cardiomyocytes;Action potential;L-type calcium current
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Marie Nováková, Ph.D., učo 1188. Changed: 26/11/2009 09:29.
Abstract
Effects of haloperidol on L-type CaV1.2 channel were studied. Calcium current was measured in whole cell patch-clamp using calcium as a charge carrier. Inhibition by haloperidol was investigated in CaV1.2 channel natively expressed in rat cardiac myocytes and recombinant cardiac (CaV1.2a) and vascular (CaV1.2b) splice variants of the channel expressed in HEK 293 cells. Haloperidol inhibited L-type calcium current in a concentration-dependent manner with a threshold of 1 nmol/l. Inhibition was not accompanied by alteration of current waveform or by shift of current-voltage relation. In a current clamp haloperidol suppressed action potential generation. 1 micromol/l of the drug shortened the action potential duration in part of the cells and suppressed fully action potential in other cells. Moderate inhibition of the L-type calcium channels by haloperidol might cause shortening of action potential.
Abstract (in Czech)
Byl zkoumán efekt haloperidolu na L-typ CaV1.2 kanálu metodou whole cell patch-clamp za použití kalcia jako nosiče, a to v kardiomyocytech a na modelu HEK293 buněk s exprimovanými vápníkovými kanály. Byla nalezena mírná inhibice L-typu vápníkových kanálů haloperidolem a také zkrácení akčního potenciálu.
Links
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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