| MRAVEC, Jozef, Petr SKŮPA, Aurélien BAILLY, Klára HOYEROVÁ, Pavel KŘEČEK, Agnieszka BIELACH, Jan PETRÁŠEK, Jing ZHANG, Vassilena GAYKOVA, York-Dieter STIERHOF, Petre I. DOBREV, Kateřina SCHWARZEROVÁ, Jakub ROLČÍK, Daniela SEIFERTOVÁ, Christian LUSCHNIG, Eva BENKOVÁ, Eva ZAŽÍMALOVÁ, Markus GEISLER and Jiří FRIML. ) Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter. Nature. Lodon, UK: Nature Publishing Group, 2009, Neuveden, No 459, p. 1136-1140. ISSN 0028-0836. |
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@article{857730,
author = {Mravec, Jozef and Skůpa, Petr and Bailly, Aurélien and Hoyerová, Klára and Křeček, Pavel and Bielach, Agnieszka and Petrášek, Jan and Zhang, Jing and Gaykova, Vassilena and Stierhof, YorkandDieter and Dobrev, Petre I. and Schwarzerová, Kateřina and Rolčík, Jakub and Seifertová, Daniela and Luschnig, Christian and Benková, Eva and Zažímalová, Eva and Geisler, Markus and Friml, Jiří},
article_location = {Lodon, UK},
article_number = {459},
keywords = {auxin; PIN5; polar auxin transport; endoplasmic reticulum; subcellular homeostasis},
language = {eng},
issn = {0028-0836},
journal = {Nature},
title = {) Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter},
volume = {Neuveden},
year = {2009}
}
TY - JOUR
ID - 857730
AU - Mravec, Jozef - Skůpa, Petr - Bailly, Aurélien - Hoyerová, Klára - Křeček, Pavel - Bielach, Agnieszka - Petrášek, Jan - Zhang, Jing - Gaykova, Vassilena - Stierhof, York-Dieter - Dobrev, Petre I. - Schwarzerová, Kateřina - Rolčík, Jakub - Seifertová, Daniela - Luschnig, Christian - Benková, Eva - Zažímalová, Eva - Geisler, Markus - Friml, Jiří
PY - 2009
TI - ) Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter
JF - Nature
VL - Neuveden
IS - 459
SP - 1136-1140
EP - 1136-1140
PB - Nature Publishing Group
SN - 00280836
KW - auxin
KW - PIN5
KW - polar auxin transport
KW - endoplasmic reticulum
KW - subcellular homeostasis
N2 - The plant signalling molecule auxin provides positional information in a variety of developmental processes by means of its differential distribution (gradients) within plant tissues. Thus, cellular auxin levels often determine the developmental output of auxin signalling. Conceptually, transmembrane transport and metabolic processes regulate the steady-state levels of auxin in any given cell. In particular, PIN auxin-efflux-carrier-mediated, directional transport between cells is crucial for generating auxin gradients. Here we show that Arabidopsis thaliana PIN5, an atypical member of the PIN gene family, encodes a functional auxin transporter that is required for auxin-mediated development. PIN5 does not have a direct role in cell-to-cell transport but regulates intracellular auxin homeostasis and metabolism. PIN5 localizes, unlike other characterized plasma membrane PIN proteins, to endoplasmic reticulum (ER), presumably mediating auxin flow from the cytosol to the lumen of the ER. The ER localization of other PIN5-like transporters (including the moss PIN) indicates that the diversification of PIN protein functions in mediating auxin homeostasis at the ER, and cell-to-cell auxin transport at the plasma membrane, represent an ancient event during the evolution of land plants.
ER -
MRAVEC, Jozef, Petr SKŮPA, Aurélien BAILLY, Klára HOYEROVÁ, Pavel KŘEČEK, Agnieszka BIELACH, Jan PETRÁŠEK, Jing ZHANG, Vassilena GAYKOVA, York-Dieter STIERHOF, Petre I. DOBREV, Kateřina SCHWARZEROVÁ, Jakub ROLČÍK, Daniela SEIFERTOVÁ, Christian LUSCHNIG, Eva BENKOVÁ, Eva ZAŽÍMALOVÁ, Markus GEISLER and Jiří FRIML. ) Subcellular homeostasis of phytohormone auxin is mediated by the ER-localized PIN5 transporter. \textit{Nature}. Lodon, UK: Nature Publishing Group, 2009, Neuveden, No~459, p.~1136-1140. ISSN~0028-0836.
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