Prediction of localization and interactions of apoptotic proteins

VAŘECHA, Miroslav, Vladimír ULMAN, Pavel MATULA and Michal KOZUBEK. Prediction of localization and interactions of apoptotic proteins. In Analytical Cytometry V. 2009. ISBN 978-80-254-2561-9.

Basic information

Original name

Prediction of localization and interactions of apoptotic proteins

Name in Czech

Predikce lokalizace a interakcí apoptotických proteinů

Authors

VAŘECHA, Miroslav (203 Czech Republic, guarantor), Vladimír ULMAN (203 Czech Republic), Pavel MATULA (203 Czech Republic) and Michal KOZUBEK (203 Czech Republic)

Edition

Analytical Cytometry V, 2009

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

Genetics and molecular biology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14330/09:00037415

Organization unit

Faculty of Informatics

ISBN

978-80-254-2561-9

UT WoS

000268893400002

Keywords (in Czech)

predikce lokalizace;AIF;endonukleáza G;AMID;fluorescenční mikroskopie;docking;modelování struktury proteinů

Keywords in English

localization prediction;AIF;endonuclease G;AMID;fluorescence microscopy;docking;protein structure modeling

Tags

CBIA

Tags

International impact, Reviewed

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Abstract

V originále

We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the lipid membranes. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modeling of proteins with unknown 3D structures. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results show data acquired using a combination of modern in silico methods and image analysis to understand the localization, interactions and functions of proteins AMID, AIF, endonuclease G, and other apoptosis-related proteins.

In Czech

Predikce lokalizace a interakcí apoptotických proteinů

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Links

LC535, research and development project	Name: Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii Investor: Ministry of Education, Youth and Sports of the CR, Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii
MSM0021622419, plan (intention)	Name: Vysoce paralelní a distribuované výpočetní systémy Investor: Ministry of Education, Youth and Sports of the CR, Highly Parallel and Distributed Computing Systems
2B06052, research and development project	Name: Vytipování markerů, screening a časná diagnostika nádorových onemocnění pomocí vysoce automatizovaného zpracování multidimenzionálních biomedicínských obrazů (Acronym: Biomarker) Investor: Ministry of Education, Youth and Sports of the CR, Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images