Prediction of localization and interactions of apoptotic proteins

VAŘECHA, Miroslav, Vladimír ULMAN, Pavel MATULA and Michal KOZUBEK. Prediction of localization and interactions of apoptotic proteins. In Analytical Cytometry V. 2009. ISBN 978-80-254-2561-9.

Basic information

• Original name: Prediction of localization and interactions of apoptotic proteins
• Name in Czech: Predikce lokalizace a interakcí apoptotických proteinů
• Authors: VAŘECHA, Miroslav (203 Czech Republic, guarantor), Vladimír ULMAN (203 Czech Republic), Pavel MATULA (203 Czech Republic) and Michal KOZUBEK (203 Czech Republic).
• Edition: Analytical Cytometry V, 2009.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: Genetics and molecular biology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14330/09:00037415
• Organization unit: Faculty of Informatics
• ISBN: 978-80-254-2561-9
• UT WoS: 000268893400002
• Keywords (in Czech): predikce lokalizace;AIF;endonukleáza G;AMID;fluorescenční mikroskopie;docking;modelování struktury proteinů
• Keywords in English: localization prediction;AIF;endonuclease G;AMID;fluorescence microscopy;docking;protein structure modeling
• Tags: CBIA
• Tags: International impact, Reviewed

Abstract

We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the lipid membranes. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modeling of proteins with unknown 3D structures. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results show data acquired using a combination of modern in silico methods and image analysis to understand the localization, interactions and functions of proteins AMID, AIF, endonuclease G, and other apoptosis-related proteins.

Abstract (in Czech)

Predikce lokalizace a interakcí apoptotických proteinů

Links

• LC535, research and development project: Name: Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii

Investor: Ministry of Education, Youth and Sports of the CR, Dynamika a organizace chromosomů během buněčného cyklu v normě a patologii

• MSM0021622419, plan (intention): Name: Vysoce paralelní a distribuované výpočetní systémy

Investor: Ministry of Education, Youth and Sports of the CR, Highly Parallel and Distributed Computing Systems

• 2B06052, research and development project: Name: Vytipování markerů, screening a časná diagnostika nádorových onemocnění pomocí vysoce automatizovaného zpracování multidimenzionálních biomedicínských obrazů (Acronym: Biomarker)

Investor: Ministry of Education, Youth and Sports of the CR, Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images