Detailed Information on Publication Record
2009
Analyzing and modelling thermodynamics; the key to lectin engineering
ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Michaela WIMMEROVÁ, Jaroslav KOČA et. al.Basic information
Original name
Analyzing and modelling thermodynamics; the key to lectin engineering
Name in Czech
Analyzing and modelling thermodynamics; the key to lectin engineering
Authors
ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Michaela WIMMEROVÁ and Jaroslav KOČA
Edition
Brno, Cukrblik 2009, p. 11-11, 2009
Publisher
Masarykova Univerzita
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
10600 1.6 Biological sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Organization unit
Faculty of Science
ISBN
978-80-210-4831-7
Keywords (in Czech)
lektiny; dokování; výpočetní chemie; termodynamika
Keywords in English
lectins; docking; computational chemistry; thermodynamics
Změněno: 9/4/2010 09:11, prof. RNDr. Michaela Wimmerová, Ph.D.
V originále
Thermodynamics is a basic driving force of all chemical processes, including those in the biomolecular chemistry. Not a single process can disobey its fundamental rules. The lectin-saccharide interaction is no exception, and as such, the understanding of the principles determining its behaviour greatly helps to elucidate the rules of the lectin-saccharide mediated processes in the nature, and, of course, also the ways of modifying them in the desired ways. Characterizing the thermodynamic behaviour of the molecules is nowadays a quite achievable feat, thanks to development on the instrumental field. Isothermal titration calorimeters requiring only small amounts of protein to provide thermodynamics information and coupled with surface plasmon resonance, a potent mean of kinetics analysis, obtaining a detailed image of the interaction becomes quite easily available. Moreover, the current computational capacity allows to perform sophisticated simulations and modelling of the biomolecular interactions.
In Czech
Termodynamika je hnaci silou veskerych chemickych procesu. Vyuzitim pokrocilych instrumentalnich metod je mozno ziskat informace o termodynamice i kinetice biomolekularnich interakci, napriklad tech, ktere se podileji na zprostredkovavani interakce hostitele s patogenem, a techto znalosti vyuzit k jejich ovlivneni kyzenym smerem. Vypocetni chemie pak nabizi radu moznosti, jak termodynamicke chovani systemu modelovat in silico a usetrit tak experimentalni cas prostrednictvim in silico identifikace smeru, kterym by se mely zmeny ubirat.
Links
| LC06030, research and development project |
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| MSM0021622413, plan (intention) |
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