Detailed Information on Publication Record
2009
CRACKING THE LECTIN CODE ; IN SILICO MODELING AND STRUCTURE-FUNCTIONAL STUDY OF PRINCIPLES DRIVING SUGAR PREFERENCE IN PAIIL FAMILY
ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Thomais CHATZIPAVLOU, Petros ZOTOS et. al.Basic information
Original name
CRACKING THE LECTIN CODE ; IN SILICO MODELING AND STRUCTURE-FUNCTIONAL STUDY OF PRINCIPLES DRIVING SUGAR PREFERENCE IN PAIIL FAMILY
Name in Czech
CRACKING THE LECTIN CODE ; IN SILICO MODELING AND STRUCTURE-FUNCTIONAL STUDY OF PRINCIPLES DRIVING SUGAR PREFERENCE IN PAIIL FAMILY
Authors
ADAM, Jan, Zdeněk KŘÍŽ, Martin PROKOP, Thomais CHATZIPAVLOU, Petros ZOTOS, Jaroslav KOČA and Michaela WIMMEROVÁ
Edition
Oxford, FEBS Journal, p. 12-13, 2 pp. 2009
Publisher
Wiley-Blackwell
Other information
Language
English
Type of outcome
Stať ve sborníku
Field of Study
10600 1.6 Biological sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 3.042
Organization unit
Faculty of Science
ISSN
UT WoS
000267069900032
Keywords (in Czech)
lectin engineering; molecular modeling; thermodynamics
Keywords in English
lectin engineering; molecular modeling; thermodynamics
Změněno: 29/4/2011 15:39, prof. RNDr. Jaroslav Koča, DrSc.
V originále
INTRODUCTION Pseudomonas aeruginosa is an opportunistic human pathogen, a bacterium capable of attacking individuals with lowered immunity barriers. It is e.g. responsible for lethal complications in patients with cystic fibrosis. The PAIIL lectin (a C type fucose-preferring lectin with sugar binding mediated by two calcium ions), produced by the bacterium plays a crucial role in the host pathogen interaction. Similar lectin sequences were found in other bacteria, displaying distinct differences in preference despite only small differences in structure of binding site. In vitro and in silico mutants were constructed in order to analyze the principles driving the sugar preference. METHODS Molecular docking was performed using the AUTODOCK and DOCK software.
In Czech
Molekulove modelovani muze vyrazne napomoci v modelovani biomolekularnich interakci, zde napriklad lektin-sacharidove interakce podilejici se na patogenicite bakterie Pseudomonas aeruginosa, jakoz i slouzit coby efektivni prostredek predpovidani chovani systemu v zavislosti na provedenych mutacich, usnadnujic tak experimentatorum cestu k porozumeni dane interakce a zpusobu, jak ji ovlivnovat cilenym smerem.
Links
| LC06030, research and development project |
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| MSM0021622413, plan (intention) |
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