| FIALOVÁ, Kateřina, Olga KRIZANOVA, Jiří JARKOVSKÝ a Marie NOVÁKOVÁ. Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment. Canadian Journal of Physiology and Pharmacology. Ottawa, Canada: National Research Council of Canada, 2009, roč. 87, č. 12, s. 1019-1027. ISSN 1205-7541. |
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@article{859083,
author = {Fialová, Kateřina and Krizanova, Olga and Jarkovský, Jiří and Nováková, Marie},
article_location = {Ottawa, Canada},
article_number = {12},
keywords = {haloperidol; sigma receptor; desensitization; rat; guinea pig; isolated heart; QT interval; arrhythmia},
language = {eng},
issn = {1205-7541},
journal = {Canadian Journal of Physiology and Pharmacology},
title = {Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment},
volume = {87},
year = {2009}
}
TY - JOUR
ID - 859083
AU - Fialová, Kateřina - Krizanova, Olga - Jarkovský, Jiří - Nováková, Marie
PY - 2009
TI - Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment
JF - Canadian Journal of Physiology and Pharmacology
VL - 87
IS - 12
SP - 1019-1027
EP - 1019-1027
PB - National Research Council of Canada
SN - 12057541
KW - haloperidol
KW - sigma receptor
KW - desensitization
KW - rat
KW - guinea pig
KW - isolated heart
KW - QT interval
KW - arrhythmia
N2 - The supposed role of cardiac sigma receptors is fine tuning of contractility. They affect several ion channels, and hence their signaling is reflected by the electrophysiological properties of the heart. Numerous ligands of sigma receptors are known to prolong QT interval and therefore cause a variety of arrhythmias, including the severe ones. The effects of prototypical sigma ligand haloperidol have been repeatedly studied in humans as well as in various animal models. We examined the incidence of arrhythmias, changes in heart rate, QT interval in isolated Langendorff-perfused rat and guinea pig hearts after they were exposed to nanomolar concentration of haloperidol. Hearts from both untreated and chronically to haloperidol exposed animals were investigated. While due to haloperidol administration, the QT prolongation and arrhythmias were observed in untreated rat and guinea pig hearts, arrhythmias were completely prevented in both chronically treated species.
ER -
FIALOVÁ, Kateřina, Olga KRIZANOVA, Jiří JARKOVSKÝ a Marie NOVÁKOVÁ. Apparent desensitization of the effects of sigma receptor ligand haloperidol in isolated rat and guinea pig hearts after chronic treatment. \textit{Canadian Journal of Physiology and Pharmacology}. Ottawa, Canada: National Research Council of Canada, 2009, roč.~87, č.~12, s.~1019-1027. ISSN~1205-7541.
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