WANG, Zhi, Christine WILHELMSSON, Pavel HYRŠL, Torsten G. LOOF, Pavel DOBEŠ, Martina KLUPP, Olga LOSEVA, Matthias MÖRGELIN, Jennifer IKLÉ, Richard M. CRIPPS, Heiko HERWALD and Ulrich THEOPOLD. Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism. PLoS Pathogens. San Francisco: Public Library Science, 2010, vol. 6, No 2, p. 1-9. ISSN 1553-7366.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism
Name in Czech Pathogen entrapment by transglutaminase - a conserved early innate immune mechanism
Authors WANG, Zhi (156 China), Christine WILHELMSSON (752 Sweden), Pavel HYRŠL (203 Czech Republic, guarantor), Torsten G. LOOF (752 Sweden), Pavel DOBEŠ (203 Czech Republic), Martina KLUPP (752 Sweden), Olga LOSEVA (752 Sweden), Matthias MÖRGELIN (752 Sweden), Jennifer IKLÉ (752 Sweden), Richard M. CRIPPS (752 Sweden), Heiko HERWALD (752 Sweden) and Ulrich THEOPOLD (752 Sweden).
Edition PLoS Pathogens, San Francisco, Public Library Science, 2010, 1553-7366.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 9.079
RIV identification code RIV/00216224:14310/10:00043068
Organization unit Faculty of Science
UT WoS 000275295900015
Keywords (in Czech) Drosophila; Immunity; Transglutaminase
Keywords in English Drosophila; Immunity; Transglutaminase
Tags International impact, Reviewed
Changed by Changed by: Mgr. Pavel Dobeš, Ph.D., učo 150960. Changed: 17/10/2010 09:56.
Abstract
Clotting systems are required in almost all animals to prevent loss of body fluids after injury. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using both a human and a natural insect pathogen we provide functional proof for an immune function for transglutaminase (TG). Drosophila larvae with reduced TG levels show increased mortality after septic injury. The same larvae are also more susceptible to a natural infection involving entomopathogenic nematodes and their symbiotic bacteria while neither phagocytosis, phenoloxidase or - as previously shown- the Toll or imd pathway contribute to immunity. These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.
Abstract (in Czech)
Clotting systems are required in almost all animals to prevent loss of body fluids after injury. We compared clotting of human blood and insect hemolymph to study the best-conserved component of clotting systems, namely the Drosophila enzyme transglutaminase and its vertebrate homologue Factor XIIIa. Using both a human and a natural insect pathogen we provide functional proof for an immune function for transglutaminase (TG). Drosophila larvae with reduced TG levels show increased mortality after septic injury. The same larvae are also more susceptible to a natural infection involving entomopathogenic nematodes and their symbiotic bacteria while neither phagocytosis, phenoloxidase or - as previously shown- the Toll or imd pathway contribute to immunity. These findings will help to guide further strategies to reduce the damaging effects of clotting and enhance its beneficial contribution to immune reactions.
PrintDisplayed: 9/7/2024 03:46