Detailed Information on Publication Record
2010
Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma.
POUR, Luděk, Hana ŠVÁCHOVÁ, Zdeněk ADAM, Zuzana MIKULKOVÁ, Ivana BUREŠOVÁ et. al.Basic information
Original name
Pretreatment hepatocyte growth factor and thrombospondin-1 levels predict response to high-dose chemotherapy for multiple myeloma.
Name in Czech
Hladiny HGF a trombospondinu 1 jsou prediktivními faktory pro odpověď na vysokodávkovanou chemoterapii u mnohočetného myelomu
Authors
POUR, Luděk (203 Czech Republic), Hana ŠVÁCHOVÁ (203 Czech Republic), Zdeněk ADAM (203 Czech Republic), Zuzana MIKULKOVÁ (203 Czech Republic), Ivana BUREŠOVÁ (203 Czech Republic), Lucie KOVÁŘOVÁ (203 Czech Republic), Tomáš BÜCHLER (703 Slovakia), Miroslav PENKA (203 Czech Republic), Jiří VORLÍČEK (203 Czech Republic) and Roman HÁJEK (203 Czech Republic, guarantor)
Edition
Neoplasma, Bratislava, Slovenská akademie věd Bratislava, 2010, 0028-2685
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30200 3.2 Clinical medicine
Country of publisher
Slovakia
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.449
RIV identification code
RIV/00216224:14110/10:00043135
Organization unit
Faculty of Medicine
UT WoS
000277412400005
Keywords (in Czech)
Angiogeneze; mnohočetný myelom; cytokiny
Keywords in English
Angiogenesis; cytokines; high-dose chemotherapy; multiple myeloma; therapeutic response
Tags
International impact, Reviewed
Změněno: 21/6/2010 15:54, Mgr. Anna Potáčová, Ph.D.
V originále
Our aim was to establish whether the pretreatment levels of angiogenesis activators and inhibitors can be used to predict clinical responses to treatment that included high-dose chemotherapy with peripheral stem cell support. Patients with complete or very good partial response had higher TSP-1 levels in the bone marrow plasma than the partial or insufficient response subgroups. There were no correlations between the pretreatment levels of VEGF, bFGF, endostatin, or angiostatin and the treatment response. Pretreatment concentrations of HGF and TSP-1 were predictive factors for treatment response. Patients with low angiogenesis rate as determined by the relative HGF and TSP-1 concentrations were more likely to achieve complete or very good partial response after high-dose chemotherapy.
In Czech
Cílem této práce bylo zjistit, zda hladiny angiogenních aktivátorů a inhibitorů mohou být využity jako prediktivní markery odpovědi na léčbu vysokodávkovanou chemoterapií s transplantací kmenových buněk. nebyly nalezeny korelace mezi hladinami VEGF, bFGF, endostatin, angiostatin a léčebnou odpovědí. Zatímco hladiny HGF a TSP-1 se jeví jako prediktivní faktory na léčebnou odpověď.
Links
| LC06027, research and development project |
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| MSM0021622434, plan (intention) |
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