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@article{865675,
author = {Rédová, Martina and Chlapek, Petr and Loja, Tomáš and Zitterbart, Karel and Hermanová, Markéta and Štěrba, Jaroslav and Veselská, Renata},
article_location = {Athens},
article_number = {2},
keywords = {neuroblastoma; caffeic acid; celecoxibe; all-trans retinoic acid; cell differentiation},
language = {eng},
issn = {1107-3756},
journal = {International Journal of Molecular Medicine},
title = {Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines.},
volume = {25},
year = {2010}
}
TY - JOUR
ID - 865675
AU - Rédová, Martina - Chlapek, Petr - Loja, Tomáš - Zitterbart, Karel - Hermanová, Markéta - Štěrba, Jaroslav - Veselská, Renata
PY - 2010
TI - Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines.
JF - International Journal of Molecular Medicine
VL - 25
IS - 2
SP - 271-280
EP - 271-280
PB - Spandidos Ltd.
SN - 11073756
KW - neuroblastoma
KW - caffeic acid
KW - celecoxibe
KW - all-trans retinoic acid
KW - cell differentiation
N2 - We investigated the possible modulation by LOX/ COX inhibitors of all-trans retinoic acid (ATRA)-induced cell differentiation in two established neuroblastoma cell lines, SH-SY5Y and SK-N-BE(2). Caffeic acid, as an inhibitor of 5-lipoxygenase, and celecoxib, as an inhibitor of cyclooxygenase-2, were chosen for this study. The effects of the combined treatment with ATRA and LOX/COX inhibitors on neuroblastoma cells were studied using cell morphology assessment, detection of differentiation markers by immunoblotting, measurement of proliferation activity, and cell cycle analysis and apoptosis detection by flow cytometry. The results clearly demonstrated the potential of caffeic acid to enhance ATRA-induced cell differentiation, especially in the SK-N-BE(2) cell line, whereas application of celecoxib alone or with ATRA led predominantly to cytotoxic effects in both cell lines.
ER -
RÉDOVÁ, Martina, Petr CHLAPEK, Tomáš LOJA, Karel ZITTERBART, Markéta HERMANOVÁ, Jaroslav ŠTĚRBA and Renata VESELSKÁ. Influence of LOX/COX inhibitors on cell differentiation induced by all-trans retinoic acid in neuroblastoma cell lines. \textit{International Journal of Molecular Medicine}. Athens: Spandidos Ltd., 2010, vol.~25, No~2, p.~271-280. ISSN~1107-3756.
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