Prediction of human papillomavirus 16 e6 gene expression and
cervical intraepithelial neoplasia progression by methylation
status

J 2009

Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status

HUBLAROVÁ, Pavla, Roman HRSTKA, Pavla ROTTEROVÁ, Leopold ROTTER, Marie ČOUPKOVÁ et. al.

Basic information

Original name

Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status

Name in Czech

Predikce exprese genu E6 lidského papillomaviru 16 a progrese cervikálních intraepiteliálních lézích určená metylací

Authors

HUBLAROVÁ, Pavla, Roman HRSTKA, Pavla ROTTEROVÁ, Leopold ROTTER, Marie ČOUPKOVÁ, Vinay BADAL, Rudolf NENUTIL and Bořivoj VOJTĚŠEK

Edition

International Journal of Gynecologic Cancer, United States, Int J Gynecol Cancer, 2009, 1048-891X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.179

Organization unit

Faculty of Medicine

UT WoS

000266976600004

Keywords (in Czech)

děložní hrdlo, intraepiteliální léze děložního hrdla, HPV16, gen E6, metylace promotoru

Keywords in English

cervix; cervical intraepithelial neoplasia; HPV16; E6 gene; promoter methylation

Abstract

ORIG CZ

V originále

Human papillomavirus (HPV) infection is the most important risk factor for development of CIN and cervical cancer. We analyse HPV16 E6 gene promoter methylation. Incidence of HPV16 significantly differed (P<0.001,chi-square test of Pearson). Methylation was detected and statistical significant differencies were found (P<0.001; Pearsons chi-square test). Methylation of the E6 gene promoter is predictive biomarker for cervical cancer progression.

In Czech

Lidské papilomaviry (HPV) jsou největším rizikem pro vznik CIN a karcinomu čípku. Analyzovali jsme metylaci promotoru genu E6 HPV16. Rozdíly v incidenci HPV16 se statisticky významně lišily (P<0.001, Pearsonův chi-square test). Podobně i frekvence detekovaných metylací byly rozdílné (P<0.001, Pearsonův chi-square test). Metylace genu a promotoru E6 HPV16 je prediktivním biomarkerem pro progresi CIN.

Links

LC06035, research and development project

Name: Centrum biofyzikální chemie, bioelektrochemie a bioanalýzy. Nové nástroje pro genomiku, proteomiku a biomedicínu.

Investor: Ministry of Education, Youth and Sports of the CR, Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine

Citovat

HUBLAROVÁ, Pavla, Roman HRSTKA, Pavla ROTTEROVÁ, Leopold ROTTER, Marie ČOUPKOVÁ, Vinay BADAL, Rudolf NENUTIL and Bořivoj VOJTĚŠEK. Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status (Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status.). International Journal of Gynecologic Cancer. United States: Int J Gynecol Cancer, 2009, vol. 19, No 3, p. 321-325. ISSN 1048-891X.

@article{865899,
   author = {Hublarová, Pavla and Hrstka, Roman and Rotterová, Pavla and Rotter, Leopold and Čoupková, Marie and Badal, Vinay and Nenutil, Rudolf and Vojtěšek, Bořivoj},
   article_location = {United States},
   article_number = {3},
   keywords = {cervix; cervical intraepithelial neoplasia; HPV16; E6 gene; promoter methylation},
   language = {eng},
   issn = {1048-891X},
   journal = {International Journal of Gynecologic Cancer},
   title = {Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status},
   url = {http://www.pubmed.gov},
   volume = {19},
   year = {2009}
}

TY  - JOUR
ID  - 865899
AU  - Hublarová, Pavla - Hrstka, Roman - Rotterová, Pavla - Rotter, Leopold - Čoupková, Marie - Badal, Vinay - Nenutil, Rudolf - Vojtěšek, Bořivoj
PY  - 2009
TI  - Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status
JF  - International Journal of Gynecologic Cancer
VL  - 19
IS  - 3
SP  - 321-325
EP  - 321-325
PB  - Int J Gynecol Cancer
SN  - 1048891X
KW  - cervix
KW  - cervical intraepithelial neoplasia
KW  - HPV16
KW  - E6 gene
KW  - promoter methylation
UR  - http://www.pubmed.gov
N2  - Human papillomavirus (HPV) infection is the most important risk factor for development of CIN and cervical cancer. We analyse HPV16 E6 gene promoter methylation. Incidence of HPV16 significantly differed (P<0.001,chi-square test of Pearson). Methylation was detected and statistical significant differencies were found (P<0.001; Pearsons chi-square test). Methylation of the E6 gene promoter is predictive biomarker for cervical cancer progression.
ER  -

HUBLAROVÁ, Pavla, Roman HRSTKA, Pavla ROTTEROVÁ, Leopold ROTTER, Marie ČOUPKOVÁ, Vinay BADAL, Rudolf NENUTIL and Bořivoj VOJTĚŠEK. Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status (Prediction of human papillomavirus 16 e6 gene expression and cervical intraepithelial neoplasia progression by methylation status.). \textit{International Journal of Gynecologic Cancer}. United States: Int J Gynecol Cancer, 2009, vol.~19, No~3, p.~321-325. ISSN~1048-891X.

Detailed Information on Publication Record