7-Hydroxylated derivatives of dehydroepiandrosterone in the
human ventricular cerebrospinal fluid

J 2009

7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid

STARKA, Luboslav, Martin HILL,, Radmila KANCHEVA, Zdeněk NOVÁK, Jan CHRASTINA et. al.

Basic information

Original name

7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid

Authors

STARKA, Luboslav, Martin HILL,, Radmila KANCHEVA, Zdeněk NOVÁK, Jan CHRASTINA, Michal POHANKA and Robert MORFIN

Edition

Neuroendocrinology Letters, Sweden, Stockholm, Maghira and Maas Publications, 2009, 0172-780X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Sweden

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.047

Organization unit

Faculty of Medicine

UT WoS

000272199300013

Keywords in English

neurosteroids; cerebrospinal fluid; third ventricle; dehydroepiandrosterone; pregnenolone; 7-hydroxy derivatives

Abstract

V originále

Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this steroid may be responsive at least by part for its physiological activity. In the ventricular cerebrospinal fluid obtained from 15 patients with hydrocephalus (8 postmenopausal women and 7 men) potentially neuroactive steroid 7-oxygenated derivatives of dehydroepiandrosterone were quantified using gas chromatography/mass spectrometry. Besides free dehydroepiandrosterone 7-oxygenated steroids such as 7 alpha- and 7 beta-hydroxy-dehydroepiandrosterone, 5-androstene-3 beta,7 alpha,17 beta-triol and 5-androstene-3 beta,7 beta,17 beta-triol in picomolar concentration in serum and cerebrospinal fluid were found. Dehydroepiandrosterone and its 7-oxygenated derivatives are present in ventricular cerebrospinal fluid in concentration 2-100 times lower than in serum.

Citovat

STARKA, Luboslav, Martin HILL,, Radmila KANCHEVA, Zdeněk NOVÁK, Jan CHRASTINA, Michal POHANKA and Robert MORFIN. 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2009, vol. 30, No 3, p. 368-372. ISSN 0172-780X.

@article{867435,
   author = {Starka, Luboslav and Hill,, Martin and Kancheva, Radmila and Novák, Zdeněk and Chrastina, Jan and Pohanka, Michal and Morfin, Robert},
   article_location = {Sweden, Stockholm},
   article_number = {3},
   keywords = {neurosteroids; cerebrospinal fluid; third ventricle; dehydroepiandrosterone; pregnenolone; 7-hydroxy derivatives},
   language = {eng},
   issn = {0172-780X},
   journal = {Neuroendocrinology Letters},
   title = {7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid},
   volume = {30},
   year = {2009}
}

TY  - JOUR
ID  - 867435
AU  - Starka, Luboslav - Hill,, Martin - Kancheva, Radmila - Novák, Zdeněk - Chrastina, Jan - Pohanka, Michal - Morfin, Robert
PY  - 2009
TI  - 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid
JF  - Neuroendocrinology Letters
VL  - 30
IS  - 3
SP  - 368-372
EP  - 368-372
PB  - Maghira and Maas Publications
SN  - 0172780X
KW  - neurosteroids
KW  - cerebrospinal fluid
KW  - third ventricle
KW  - dehydroepiandrosterone
KW  - pregnenolone
KW  - 7-hydroxy derivatives
N2  - Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this steroid may be responsive at least by part for its physiological activity. In the ventricular cerebrospinal fluid obtained from 15 patients with hydrocephalus (8 postmenopausal women and 7 men) potentially neuroactive steroid 7-oxygenated derivatives of dehydroepiandrosterone were quantified using gas chromatography/mass spectrometry. Besides free dehydroepiandrosterone 7-oxygenated steroids such as 7 alpha- and 7 beta-hydroxy-dehydroepiandrosterone, 5-androstene-3 beta,7 alpha,17 beta-triol and 5-androstene-3 beta,7 beta,17 beta-triol in picomolar concentration in serum and cerebrospinal fluid were found. Dehydroepiandrosterone and its 7-oxygenated derivatives are present in ventricular cerebrospinal fluid in concentration 2-100 times lower than in serum.
ER  -

STARKA, Luboslav, Martin HILL,, Radmila KANCHEVA, Zdeněk NOVÁK, Jan CHRASTINA, Michal POHANKA and Robert MORFIN. 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid. \textit{Neuroendocrinology Letters}. Sweden, Stockholm: Maghira and Maas Publications, 2009, vol.~30, No~3, p.~368-372. ISSN~0172-780X.

Detailed Information on Publication Record