| STARKA, Luboslav, Martin HILL,, Radmila KANCHEVA, Zdeněk NOVÁK, Jan CHRASTINA, Michal POHANKA and Robert MORFIN. 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2009, vol. 30, No 3, p. 368-372. ISSN 0172-780X. |
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@article{867435,
author = {Starka, Luboslav and Hill,, Martin and Kancheva, Radmila and Novák, Zdeněk and Chrastina, Jan and Pohanka, Michal and Morfin, Robert},
article_location = {Sweden, Stockholm},
article_number = {3},
keywords = {neurosteroids; cerebrospinal fluid; third ventricle; dehydroepiandrosterone; pregnenolone; 7-hydroxy derivatives},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid},
volume = {30},
year = {2009}
}
TY - JOUR
ID - 867435
AU - Starka, Luboslav - Hill,, Martin - Kancheva, Radmila - Novák, Zdeněk - Chrastina, Jan - Pohanka, Michal - Morfin, Robert
PY - 2009
TI - 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid
JF - Neuroendocrinology Letters
VL - 30
IS - 3
SP - 368-372
EP - 368-372
PB - Maghira and Maas Publications
SN - 0172780X
KW - neurosteroids
KW - cerebrospinal fluid
KW - third ventricle
KW - dehydroepiandrosterone
KW - pregnenolone
KW - 7-hydroxy derivatives
N2 - Dehydroepiandrosterone is a long established neuroactive steroid. Some authors documented that 7-oxygenated derivatives of this steroid may be responsive at least by part for its physiological activity. In the ventricular cerebrospinal fluid obtained from 15 patients with hydrocephalus (8 postmenopausal women and 7 men) potentially neuroactive steroid 7-oxygenated derivatives of dehydroepiandrosterone were quantified using gas chromatography/mass spectrometry. Besides free dehydroepiandrosterone 7-oxygenated steroids such as 7 alpha- and 7 beta-hydroxy-dehydroepiandrosterone, 5-androstene-3 beta,7 alpha,17 beta-triol and 5-androstene-3 beta,7 beta,17 beta-triol in picomolar concentration in serum and cerebrospinal fluid were found. Dehydroepiandrosterone and its 7-oxygenated derivatives are present in ventricular cerebrospinal fluid in concentration 2-100 times lower than in serum.
ER -
STARKA, Luboslav, Martin HILL,, Radmila KANCHEVA, Zdeněk NOVÁK, Jan CHRASTINA, Michal POHANKA and Robert MORFIN. 7-Hydroxylated derivatives of dehydroepiandrosterone in the human ventricular cerebrospinal fluid. \textit{Neuroendocrinology Letters}. Sweden, Stockholm: Maghira and Maas Publications, 2009, vol.~30, No~3, p.~368-372. ISSN~0172-780X.
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