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@article{869081,
author = {Salzman, Richard and Pácal, Lukáš and Tomandl, Josef and Kaňková, Kateřina and Tothova, Eva and Gál, Břetislav and Kostřica, Rom},
article_location = {Greece},
article_number = {29},
keywords = {head and neck carcinoma prognosis oxidative stress malondialdehyde},
language = {eng},
issn = {0250-7005},
journal = {Anticancer Research},
title = {Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer},
volume = {10/2009},
year = {2009}
}
TY - JOUR
ID - 869081
AU - Salzman, Richard - Pácal, Lukáš - Tomandl, Josef - Kaňková, Kateřina - Tothova, Eva - Gál, Břetislav - Kostřica, Rom
PY - 2009
TI - Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer
JF - Anticancer Research
VL - 10/2009
IS - 29
SP - 4227-4231
EP - 4227-4231
PB - INT INST ANTICANCER RESEARCH
SN - 02507005
KW - head and neck carcinoma prognosis oxidative stress malondialdehyde
N2 - There is substantial evidence that oxidative stress participates in carcinogenesis (1-4). Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. ROS-induced damage of macromolecules can lead to changes of their structure and, consequently, function. Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress (2-6). In addition, MDA is suggested to act as a tumor promoter and co-carcinogenic agent due to its high cytotoxicity (2, 3).
ER -
SALZMAN, Richard, Lukáš PÁCAL, Josef TOMANDL, Kateřina KAŇKOVÁ, Eva TOTHOVA, Břetislav GÁL and Rom KOSTŘICA. Elevated Malondialdehyde Correlates with the Extent of Primary Tumor and Predicts Poor Prognosis of Oropharyngeal Cancer. \textit{Anticancer Research}. Greece: INT INST ANTICANCER RESEARCH, 2009, 10/2009, No~29, p.~4227-4231. ISSN~0250-7005.
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