Bullous pemphigoid and internal diseases: A case-control study.

JEDLIČKOVÁ, Hana, Miloslav HLUBINKA, Tomáš PAVLÍK, Věra SEMRÁDOVÁ, Eva BUDINSKÁ and Zdeněk VLAŠÍN. Bullous pemphigoid and internal diseases: A case-control study. European Journal of Dermatology. Francie: John Libbey Eurotext, 2010, vol. 20, No 1, p. 96-101. ISSN 1167-1122.

Basic information

• Original name: Bullous pemphigoid and internal diseases: A case-control study.
• Authors: JEDLIČKOVÁ, Hana (203 Czech Republic, guarantor), Miloslav HLUBINKA (203 Czech Republic), Tomáš PAVLÍK (203 Czech Republic), Věra SEMRÁDOVÁ (203 Czech Republic), Eva BUDINSKÁ (703 Slovakia) and Zdeněk VLAŠÍN (203 Czech Republic).
• Edition: European Journal of Dermatology, Francie, John Libbey Eurotext, 2010, 1167-1122.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30200 3.2 Clinical medicine
• Country of publisher: France
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.421
• RIV identification code: RIV/00216224:14110/10:00043272
• Organization unit: Faculty of Medicine
• UT WoS: 000274218000015
• Keywords in English: bullous pemphigoid; cancer; diabetes mellitus; etiopathogenesis; neurological disorder
• Tags: International impact, Reviewed

Abstract

To study associations of bullous pemphigoid (BP) with internal diseases, we conducted a retrospective case control study assessing the frequency of selected diseases: diabetes mellitus, neurological diseases, malignant tumors, benign prostate hyperplasia, hypertension and ischemic heart disease in patients with BP. 89 atients with BP, whose data were retrieved from the register of the Centre of bullous diseases from the period of 1991-2006, were matched with 89 controls of the same age and gender, recruited from patients treated for other skin diseases. The frequency of internal diseases at the time of the onset of BP was evaluated by unconditional logistic regression adjusted for age and gender and maximum likelihood test for contingency tables. Neurological disease was found in 42.7% of the patients and in 19.1% of controls. This difference was statistically significant (p value = 0.001). Moreover, regression analysis has shown that patients with neurological disease in the age group > 80 years have significantly higher risk of pemphigoid than patients without neurological disease (odds ratio 10.55; 95% confidence interval 2.68 to 41.49). Most frequent were cerebral stroke in men and dementia in women. For other diseases and other age groups, no statistically significant influence was found.