Matrix metalloproteinase-2 and oxidative stress in patients
with STEMI treated by primary PCI

a 2009

Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK et. al.

Basic information

Original name

Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI

Authors

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK, Zdena ČERMÁKOVÁ, Ondřej TOMAN, Daniela TOMČÍKOVÁ and Jindřich ŠPINAR

Edition

ESC CONGRESS 2009, 2009

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

Genetics and molecular biology

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

UT WoS

000208702604134

Keywords (in Czech)

MMP2, gen, polymorfismus

Keywords in English

MMP2, gene, polymorphism, MI

Změněno: 1/2/2010 13:24, prof. RNDr. Monika Pávková Goldbergová, Ph.D.

Abstract

V originále

Myocardial infarction (MI) following reparative processes include inflammatory cell infiltration, activation of matrix metalloproteinases (MMPs – family of Zn-dependent endopeptidases), extracellular matrix remodeling and scar formation. The goal of the study was the exploration of MMP-2 serum activity early after MI and its assocition with signs of acute heart failure (AHF), left ventricle systolic dysfunction, with hospital mortality and oxidative stress. Population and methods: A total of 311 patients (75% male, age 62,7 years) with acute MI with ST elevations treated by primary PCI (without AHF – 220 pts, with AHF 91 pts). Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA). MMP-2 (value B), Troponin I, BNP, NT-proBNP, malondialdehyd (MDA), TNF-alfa, vitamine A and E, uric acid were eveluated 24 hours after chest pain occurance. MMP-2 (value A) was also evaluated during admission before primary PCI, we count difference of MMP-2 (value A-B) during admission and after 24 hours. Left ventriculography was done and dP/dt/P and LVEDP was measured before primary PCI.

Links

NR9356, research and development project

Name: Komplexní zhodnocení vlivu polymorfismu matrix metalloproteináz-1,2,3,9, tkáńového inhibitoru matrix metaloproteináz-1 a ACE na remodelaci levé komory a střednědobou prognózu po akutním infarktu mykardu s ST elevacemi léčeném primární PCI

Investor: Ministry of Health of the CR, Complex estimation of relation of MMP-1,2,3,9,TIMP-1 and ACE polymorphisms to left ventricuzlar remodelation and to medium-term prognosis after acute infarct myocardum with ST elevation treated by primary PCI

Citovat

PAŘENICA, Jiří, Monika PÁVKOVÁ GOLDBERGOVÁ, Petr KALA, Martin POLOCZEK, Jan MAŇOUSEK, Zdena ČERMÁKOVÁ, Ondřej TOMAN, Daniela TOMČÍKOVÁ and Jindřich ŠPINAR. Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI. In ESC CONGRESS 2009. 2009.

@proceedings{869982,
   author = {Pařenica, Jiří and Pávková Goldbergová, Monika and Kala, Petr and Poloczek, Martin and Maňousek, Jan and Čermáková, Zdena and Toman, Ondřej and Tomčíková, Daniela and Špinar, Jindřich},
   booktitle = {ESC CONGRESS 2009},
   keywords = {MMP2, gene, polymorphism, MI},
   language = {eng},
   title = {Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI},
   year = {2009}
}

TY  - CONF
ID  - 869982
AU  - Pařenica, Jiří - Pávková Goldbergová, Monika - Kala, Petr - Poloczek, Martin - Maňousek, Jan - Čermáková, Zdena - Toman, Ondřej - Tomčíková, Daniela - Špinar, Jindřich
PY  - 2009
TI  - Matrix metalloproteinase-2 and oxidative stress in patients with STEMI treated by primary PCI
KW  - MMP2, gene, polymorphism, MI
N2  - Myocardial infarction (MI) following reparative processes include inflammatory cell infiltration, activation of matrix metalloproteinases (MMPs – family of Zn-dependent endopeptidases), extracellular matrix remodeling and scar formation. The goal of the study was the exploration of MMP-2 serum activity early after MI and its assocition with signs of acute heart failure (AHF), left ventricle systolic dysfunction, with hospital mortality and oxidative stress. Population and methods: A total of 311 patients (75% male, age 62,7 years) with acute MI with ST elevations treated by primary PCI (without AHF – 220 pts, with AHF 91 pts). Echocardiography was done from 3rd day after MI during hospitalization, left ventricular systolic dysfunction was assessed according to ejection fraction (EF) and end-diastolic volume corrected for BSA (EDV/BSA). MMP-2 (value B), Troponin I, BNP, NT-proBNP, malondialdehyd (MDA), TNF-alfa, vitamine A and E, uric acid were eveluated 24 hours after chest pain occurance. MMP-2 (value A) was also evaluated during admission before primary PCI, we count difference of MMP-2 (value A-B) during admission and after 24 hours. Left ventriculography was done and dP/dt/P and LVEDP was measured before primary PCI.
ER  -

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