| GREŠLIKOVÁ, Henrieta, Romana ZAORALOVÁ, Hana FILKOVÁ, Pavel NĚMEC, Alexandra OLTOVÁ, Renata KUPSKÁ, Petra RUDOLECKÁ, Jan SMETANA, Luděk POUR, Lenka ZAHRADOVÁ, Marta KREJČÍ, Tomáš BÜCHLER, Zdeněk ADAM, Roman HÁJEK a Petr KUGLÍK. Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation. Neoplasma. Bratislava, Slovakia: Slovak Academy of Sciences, roč. 57, č. 2, s. 111-117. ISSN 0028-2685. 2010. |
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@article{870094,
author = {Grešliková, Henrieta and Zaoralová, Romana and Filková, Hana and Němec, Pavel and Oltová, Alexandra and Kupská, Renata and Rudolecká, Petra and Smetana, Jan and Pour, Luděk and Zahradová, Lenka and Krejčí, Marta and Büchler, Tomáš and Adam, Zdeněk and Hájek, Roman and Kuglík, Petr},
article_location = {Bratislava, Slovakia},
article_number = {2},
keywords = {multiple myeloma; cytogenetics;FISH;chromosomal abnormalities;transplantation;chemotherapy.},
language = {eng},
issn = {0028-2685},
journal = {Neoplasma},
title = {Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation},
volume = {57},
year = {2010}
}
TY - JOUR
ID - 870094
AU - Grešliková, Henrieta - Zaoralová, Romana - Filková, Hana - Němec, Pavel - Oltová, Alexandra - Kupská, Renata - Rudolecká, Petra - Smetana, Jan - Pour, Luděk - Zahradová, Lenka - Krejčí, Marta - Büchler, Tomáš - Adam, Zdeněk - Hájek, Roman - Kuglík, Petr
PY - 2010
TI - Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation
JF - Neoplasma
VL - 57
IS - 2
SP - 111-117
EP - 111-117
PB - Slovak Academy of Sciences
SN - 00282685
KW - multiple myeloma
KW - cytogenetics;FISH;chromosomal abnormalities;transplantation;chemotherapy.
N2 - Malignant plasma cells in multiple myeloma (MM) are frequently characterized by complex karyotypes and chromosome instability. These cytogenetic changes are considered important prognostic indicators in MM patients. We have studied samples from 68 patients with newly diagnosed MM who were treated with high-dose chemotherapy and autologous stem cell transplantation. Our results show a high incidence of chromosomal abnormalities in MM patients and confirm the prognostic impact of selected chromosomal aberrations as well as cumulative effect of multiple cytogenetic changes occurring simultaneously.
ER -
GREŠLIKOVÁ, Henrieta, Romana ZAORALOVÁ, Hana FILKOVÁ, Pavel NĚMEC, Alexandra OLTOVÁ, Renata KUPSKÁ, Petra RUDOLECKÁ, Jan SMETANA, Luděk POUR, Lenka ZAHRADOVÁ, Marta KREJČÍ, Tomáš BÜCHLER, Zdeněk ADAM, Roman HÁJEK a Petr KUGLÍK. Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation. \textit{Neoplasma}. Bratislava, Slovakia: Slovak Academy of Sciences, roč.~57, č.~2, s.~111-117. ISSN~0028-2685. 2010.
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