A 2009

Rad52 Sumoylation Affects the Efficiency of the Recombination and DNA Repair

ALTMANNOVÁ, Veronika, Nadine ECKERTBOULET, Milica ARNERIC, Peter KOLESÁR, Xiaolan ZHAO et. al.

Basic information

Original name

Rad52 Sumoylation Affects the Efficiency of the Recombination and DNA Repair

Authors

ALTMANNOVÁ, Veronika, Nadine ECKERTBOULET, Milica ARNERIC, Peter KOLESÁR, Xiaolan ZHAO, Michael LISBY and Lumír KREJČÍ

Edition

2009

Other information

Language

English

Type of outcome

Audiovizuální tvorba

Field of Study

10600 1.6 Biological sciences

Country of publisher

Netherlands

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Science

Keywords (in Czech)

Rad52; sumoylace; homologní rekombinace

Keywords in English

Rad52; sumoylation; homologous recombination

Tags

International impact
Změněno: 9/4/2010 12:22, doc. Mgr. Lumír Krejčí, Ph.D.

Abstract

V originále

Homologous recombination (HR) plays a vital role in DNA metabolic processes including meiosis, DNA repair, DNA replication, and maintenance of rDNA homeostasis. Defects in HR can lead to pathological outcomes, including genetic diseases and cancer. Recent studies suggest that the post-translational modification by small ubiquitin-like modifier (SUMO) protein plays an important role in mitotic and meiotic recombination but its precise function is still unclear. We will present the characterization of the novel effect of SUMOylation on the properties of Saccharomyces cerevisiae mediator protein Rad52.

Links

GA301/09/1917, research and development project
Name: Štěpení replikačních-rekombinačních DNA meziproduktů a jejich úloha při nestabilitě genomu
Investor: Czech Science Foundation
GD203/09/H046, research and development project
Name: Biochemie na rozcestí mezi in silico a in vitro
Investor: Czech Science Foundation
LC06030, research and development project
Name: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)
Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment