CHEN, K., Weifeng XU, Melanie WILSON, Bing HE, WNorman MILLER, Eva BENGTÉM, Eva-Stina EDHOLM, Paul A SANTINI, Poonam RATH, April CHIU, Marco CATTALINI, Jiří LITZMAN, James B BUSSEL, Bihui HUANG, Antonella MEINI, Kristian RIESBECK, Charlotte CUNNINGHAM-RUNDLES, Alessandro PLEBANI a Andrea CERUTTI. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. Nature immunology. roč. 10, č. 8, s. 889-898. ISSN 1529-2908. 2009. |
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@article{871591, author = {Chen, K. and Xu, Weifeng and Wilson, Melanie and He, Bing and Miller, WNorman and Bengtém, Eva and Edholm, EvaandStina and Santini, Paul A and Rath, Poonam and Chiu, April and Cattalini, Marco and Litzman, Jiří and Bussel, James B and Huang, Bihui and Meini, Antonella and Riesbeck, Kristian and CunninghamandRundles, Charlotte and Plebani, Alessandro and Cerutti, Andrea}, article_number = {8}, keywords = {Immunoglobulin D; basophils; cytokine expression}, language = {eng}, issn = {1529-2908}, journal = {Nature immunology}, title = {Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils}, volume = {10}, year = {2009} }
TY - JOUR ID - 871591 AU - Chen, K. - Xu, Weifeng - Wilson, Melanie - He, Bing - Miller, WNorman - Bengtém, Eva - Edholm, Eva-Stina - Santini, Paul A - Rath, Poonam - Chiu, April - Cattalini, Marco - Litzman, Jiří - Bussel, James B - Huang, Bihui - Meini, Antonella - Riesbeck, Kristian - Cunningham-Rundles, Charlotte - Plebani, Alessandro - Cerutti, Andrea PY - 2009 TI - Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils JF - Nature immunology VL - 10 IS - 8 SP - 889-898 EP - 889-898 SN - 15292908 KW - Immunoglobulin D KW - basophils KW - cytokine expression N2 - Immunoglobulin D (IgD) is an enigmatic antibody isotype that mature B cells express together with IgM through alternative RNA splicing. Here we report active T cell-dependent and T cell-independent IgM-to-IgD class switching in B cells of the human upper respiratory mucosa. This process required activation-induced cytidine deaminase (AID) and generated local and circulating IgD-producing plasmablasts reactive to respiratory bacteria. Circulating IgD bound to basophils through a calcium-mobilizing receptor that induced antimicrobial, opsonizing, inflammatory and B cell-stimulating factors, including cathelicidin, interleukin 1 (IL-1), IL-4 and B cell-activating factor (BAFF), after IgD crosslinking. By showing dysregulation of IgD class-switched B cells and 'IgD-armed' basophils in autoinflammatory syndromes with periodic fever, our data indicate that IgD orchestrates an ancestral surveillance system at the interface between immunity and inflammation. ER -
CHEN, K., Weifeng XU, Melanie WILSON, Bing HE, WNorman MILLER, Eva BENGTÉM, Eva-Stina EDHOLM, Paul A SANTINI, Poonam RATH, April CHIU, Marco CATTALINI, Jiří LITZMAN, James B BUSSEL, Bihui HUANG, Antonella MEINI, Kristian RIESBECK, Charlotte CUNNINGHAM-RUNDLES, Alessandro PLEBANI a Andrea CERUTTI. Immunoglobulin D enhances immune surveillance by activating antimicrobial, proinflammatory and B cell-stimulating programs in basophils. \textit{Nature immunology}. roč.~10, č.~8, s.~889-898. ISSN~1529-2908. 2009.
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