Combined treatment of achalasia - botulinum toxin injection
followed by pneumatic dilatation: long-term results

J 2010

Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results

KROUPA, Radek, Aleš HEP, Jiří DOLINA, Vlastimil VÁLEK, Zuzana MATYÁŠOVÁ et. al.

Basic information

Original name

Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results

Authors

KROUPA, Radek (203 Czech Republic, guarantor, belonging to the institution), Aleš HEP (203 Czech Republic, belonging to the institution), Jiří DOLINA (203 Czech Republic, belonging to the institution), Vlastimil VÁLEK (203 Czech Republic, belonging to the institution), Zuzana MATYÁŠOVÁ (203 Czech Republic), Jitka PROKEŠOVÁ (203 Czech Republic, belonging to the institution), Jaroslav SEDMÍK (203 Czech Republic, belonging to the institution) and Ivo NOVOTNÝ (203 Czech Republic, belonging to the institution)

Edition

Diseases of the Esophagus, Wiley blackwell, 2010, 1120-8694

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.536

RIV identification code

RIV/00216224:14110/10:00043346

Organization unit

Faculty of Medicine

UT WoS

000274622100003

Keywords in English

achalasia - botulinum toxin- pneumatic dilatatation- therapy

Abstract

V originále

Injection of botulinum toxin (BT) and pneumatic dilatation are available methods in nonsurgical treatment of achalasia. Authors anticipate beneficial effect of prior BT injection on the success of pneumatic dilatation and duration of its effect. There are no long-term data available to assess efficacy of combined treatment.Result of prospective study on 51 consecutive patients treated by comination method are presented. The cumulative 5 years remission rate in combined treated patients 69% was higher than in controls 50%; however it, was not statistically significant (P = 0.07). Eight patients (17%) with relapse of dysphagia were referred to laparoscopic Heller myotomy with no surgical complication.Initial injection of BT followed by PD seems to be effective for long-term results with fewer complications. But the combined therapy is not significantly superior to PD alone.

Links

2B06060, research and development project

Name: Zefektivnění diagnostiky a léčby gastroezofageální refluxní choroby jícnu (Acronym: NPVII11002)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

KROUPA, Radek, Aleš HEP, Jiří DOLINA, Vlastimil VÁLEK, Zuzana MATYÁŠOVÁ, Jitka PROKEŠOVÁ, Jaroslav SEDMÍK and Ivo NOVOTNÝ. Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results. Diseases of the Esophagus. Wiley blackwell, 2010, vol. 23, No 2, p. 100-105. ISSN 1120-8694.

@article{871629,
   author = {Kroupa, Radek and Hep, Aleš and Dolina, Jiří and Válek, Vlastimil and Matyášová, Zuzana and Prokešová, Jitka and Sedmík, Jaroslav and Novotný, Ivo},
   article_number = {2},
   keywords = {achalasia - botulinum toxin- pneumatic dilatatation- therapy},
   language = {eng},
   issn = {1120-8694},
   journal = {Diseases of the Esophagus},
   title = {Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results},
   volume = {23},
   year = {2010}
}

TY  - JOUR
ID  - 871629
AU  - Kroupa, Radek - Hep, Aleš - Dolina, Jiří - Válek, Vlastimil - Matyášová, Zuzana - Prokešová, Jitka - Sedmík, Jaroslav - Novotný, Ivo
PY  - 2010
TI  - Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results
JF  - Diseases of the Esophagus
VL  - 23
IS  - 2
SP  - 100-105
EP  - 100-105
PB  - Wiley blackwell
SN  - 11208694
KW  - achalasia - botulinum toxin- pneumatic dilatatation- therapy
N2  - Injection of botulinum toxin (BT) and pneumatic dilatation are available methods in nonsurgical treatment of achalasia. Authors anticipate beneficial effect of prior BT injection on the success of pneumatic dilatation and duration of its effect. There are no long-term data available to assess efficacy of combined treatment.Result of prospective study on 51 consecutive patients treated by comination method are presented. The cumulative 5 years remission rate in combined treated patients 69% was higher than in controls 50%; however it, was not statistically significant (P = 0.07). Eight patients (17%) with relapse of dysphagia were referred to laparoscopic Heller myotomy with no surgical complication.Initial injection of BT followed by PD seems to be effective for long-term results with fewer complications. But the combined therapy is not significantly superior to PD alone.
ER  -

KROUPA, Radek, Aleš HEP, Jiří DOLINA, Vlastimil VÁLEK, Zuzana MATYÁŠOVÁ, Jitka PROKEŠOVÁ, Jaroslav SEDMÍK and Ivo NOVOTNÝ. Combined treatment of achalasia - botulinum toxin injection followed by pneumatic dilatation: long-term results. \textit{Diseases of the Esophagus}. Wiley blackwell, 2010, vol.~23, No~2, p.~100-105. ISSN~1120-8694.

Detailed Information on Publication Record