KUBÍČEK, Karel, Jordan MONNET, Simone SCINTILLA, Jana KOPEČNÁ, Fabio ARNESANO, Lukáš TRANTÍREK, Claude CHOPARD, Giovanni NATILE and Jiří KOZELKA. Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex. Chemistry - An Asian Journal. WILEY-V C H VERLAG GMBH, 2010, vol. 5, No 2, p. 244-247. ISSN 1861-4728.
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Basic information
Original name Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex
Authors KUBÍČEK, Karel (203 Czech Republic, belonging to the institution), Jordan MONNET (250 France), Simone SCINTILLA (380 Italy), Jana KOPEČNÁ (203 Czech Republic), Fabio ARNESANO (380 Italy), Lukáš TRANTÍREK (203 Czech Republic), Claude CHOPARD (250 France), Giovanni NATILE (380 Italy) and Jiří KOZELKA (250 France, guarantor, belonging to the institution).
Edition Chemistry - An Asian Journal, WILEY-V C H VERLAG GMBH, 2010, 1861-4728.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10610 Biophysics
Country of publisher Germany
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 4.188
RIV identification code RIV/00216224:14310/10:00043383
Organization unit Faculty of Science
UT WoS 000274539100003
Keywords (in Czech) DNA struktury; meziřetězcové kroslinky; molekulární modelování; NMR spektroskopie; platina
Keywords in English DNA structures; interstrand crosslinks; molecular modeling; NMR spectroscopy; platinum
Tags Reviewed
Changed by Changed by: doc. Mgr. Karel Kubíček, PhD., učo 20563. Changed: 27/1/2011 15:46.
Abstract
An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-di-aminocyclohexane)2+ (the enantiomer of the antitumor drug oxaliplatin). The final product provides a rare example of intramolecular self-intercalation of DNA.
Abstract (in Czech)
Neobvyklý G6G11 kroslink vzniká spontánním přeuspořádáním kanonického intrařetězcového kroslinku G5G6, který vznikl z DNA duplexu d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) a Pt(S,S-di-aminocyclohexan)2+. Výsledný produkt je jedním z mála příkladu intramulekulární self-interkalace DNA.
Links
GP202/08/P416, research and development projectName: Studium interakce mezi cisplatinovanou G/T "mismatched" DNA s proteinem MutS pomocí NMR
Investor: Czech Science Foundation, NMR study of interaction of cisplatined G/T mismatched DNA substrate with protein MutS
MUNI/A/1046/2009, interní kód MUName: Biofyzikální výzkum struktur a funkcí biomolekul (Acronym: BVSFB)
Investor: Masaryk University, Category A
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