| PACLT, Ivo, Ivana DRTÍLKOVÁ, Marta KOPEČKOVÁ, Pavel THEINER, Omar ŠERÝ and Naďa ČERMÁKOVÁ. The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years. Neuroendocrinology Letters. Sweden, Stockholm: Maghira and Maas Publications, 2010, vol. 31, No 1, p. 23-28. ISSN 0172-780X. |
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@article{873258,
author = {Paclt, Ivo and Drtílková, Ivana and Kopečková, Marta and Theiner, Pavel and Šerý, Omar and Čermáková, Naďa},
article_location = {Sweden, Stockholm},
article_number = {1},
keywords = {ADHD association DRD2},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinology Letters},
title = {The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years},
volume = {31},
year = {2010}
}
TY - JOUR
ID - 873258
AU - Paclt, Ivo - Drtílková, Ivana - Kopečková, Marta - Theiner, Pavel - Šerý, Omar - Čermáková, Naďa
PY - 2010
TI - The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years
JF - Neuroendocrinology Letters
VL - 31
IS - 1
SP - 23-28
EP - 23-28
PB - Maghira and Maas Publications
SN - 0172780X
KW - ADHD association DRD2
N2 - OBJECTIVE: The purpose of this study was the correlation of the combined type of ADHD in children and Taq IA polymorphism DRD2 gene. We hypothesized a positive correlation of DRD2 polymorphisms in the combined type of ADHD patients without co-morbidity. PatientS AND METHODS: Our research sample included 586 unrelated boys of the Czech origin aged between 6 and 13 years. The ADHD group consisted of 269 boys and the control group consisted of 317 boys. PCR detection of the DRD2 polymorphism was carried out by using primers, described by Grandy (Grandy et al. 1989). RESULTS: The comparison of genotype frequencies showed statistically highly significant difference between the studied groups (p<0.0001). A statistically significant difference was also found when the allelic frequencies between the two groups were compared (p<0.0001), with the A1 allele having a 4.359 fold higher risk of ADHD (Risk Ratio=4.359, 95% CI of RR=3.5753 to 5.3144, Odds Ratio= 7.7824; 95% CI of OR=10.315 to 13.6719).
ER -
PACLT, Ivo, Ivana DRTÍLKOVÁ, Marta KOPEČKOVÁ, Pavel THEINER, Omar ŠERÝ and Naďa ČERMÁKOVÁ. The association between TaqI A polymorphism of ANKK1 (DRD2) gene and ADHD in the Czech boys aged between 6 and 13 years. \textit{Neuroendocrinology Letters}. Sweden, Stockholm: Maghira and Maas Publications, 2010, vol.~31, No~1, p.~23-28. ISSN~0172-780X.
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