| MATĚJKOVÁ POSPÍŠILOVÁ, Petra, Magdalena FLASAROVÁ, Hana ZÁKOUCKÁ, M. BOŘEK, Gabriela KŘEMENOVÁ, P. ARENBERGER, Vladana WOZNICOVÁ, G. M. WEINSTOCK and David ŠMAJS. Screening of macrolide resistance locus in Treponema pallidum subsp. pallidum in the Czech Republic. In Clinical Microbiology and Infection, Abstracts of the 19th ECCMID, P698. Neuveden: European Society of Clinical Microbiology and Infectious Diseases, 2009, p. 168. ISSN 1198-743X. |
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@inproceedings{873304,
author = {Matějková Pospíšilová, Petra and Flasarová, Magdalena and Zákoucká, Hana and Bořek, M. and Křemenová, Gabriela and Arenberger, P. and Woznicová, Vladana and Weinstock, G. M. and Šmajs, David},
address = {Neuveden},
booktitle = {Clinical Microbiology and Infection, Abstracts of the 19th ECCMID, P698},
keywords = {macrolide resistance; 23S rRNA; syphilis},
language = {eng},
location = {Neuveden},
pages = {168-168},
publisher = {European Society of Clinical Microbiology and Infectious Diseases},
title = {Screening of macrolide resistance locus in Treponema pallidum subsp. pallidum in the Czech Republic.},
url = {http://www3.interscience.wiley.com/cgi-bin/fulltext/122401282/PDFSTART},
year = {2009}
}
TY - JOUR
ID - 873304
AU - Matějková Pospíšilová, Petra - Flasarová, Magdalena - Zákoucká, Hana - Bořek, M. - Křemenová, Gabriela - Arenberger, P. - Woznicová, Vladana - Weinstock, G. M. - Šmajs, David
PY - 2009
TI - Screening of macrolide resistance locus in Treponema pallidum subsp. pallidum in the Czech Republic.
PB - European Society of Clinical Microbiology and Infectious Diseases
CY - Neuveden
KW - macrolide resistance
KW - 23S rRNA
KW - syphilis
UR - http://www3.interscience.wiley.com/cgi-bin/fulltext/122401282/PDFSTART
N2 - Due to alergies to penicillin, macrolide regimens are frequently applied in the treatment of syphilis. A2058G mutation in the 23S rDNA locus was described to cause erythromycin resistance in syphilis.Molecular detection of syphilis represents the only available test to reveal macrolide resistance in clinical isolates, because T. pallidum can not be cultured in vitro. The set of 28 clinical isolates with detectable genetic material were collected from 22 patients in the Czech Republic in the time period 2005 to 2008. Four patients (18.2%) were diagnosed with a strain bearing the A2058G transition and four patients (18.2%) with a strain bearing the A2059G mutation. Screening of clinical samples revealed a novel mutation at the position 2059 of the T. pallidum 23S rRNA gene that causes macrolide resistance in several other bacteria. Our results show that macrolide resistant isolates of T. pallidum bearing A2058G and A2059G mutations are relatively abundant in the Czech Republic.
ER -
MATĚJKOVÁ POSPÍŠILOVÁ, Petra, Magdalena FLASAROVÁ, Hana ZÁKOUCKÁ, M. BOŘEK, Gabriela KŘEMENOVÁ, P. ARENBERGER, Vladana WOZNICOVÁ, G. M. WEINSTOCK and David ŠMAJS. Screening of macrolide resistance locus in Treponema pallidum subsp. pallidum in the Czech Republic. In \textit{Clinical Microbiology and Infection, Abstracts of the 19th ECCMID, P698}. Neuveden: European Society of Clinical Microbiology and Infectious Diseases, 2009, p.~168. ISSN~1198-743X.
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