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@proceedings{873354, author = {Zgažarová, Simona and Jedličková, Hana and Thon, Vojtěch}, booktitle = {Book of abstracts na CD - International congress of dermatology. Praha}, keywords = {drug hypersensitivity; delayed reaction; tribenoside; patch test; lymphocyte transformation test; basophil activation test}, language = {eng}, title = {The evaluation of hypersensitivity to tribenoside (Glyvenol)}, year = {2009} }
TY - CONF ID - 873354 AU - Zgažarová, Simona - Jedličková, Hana - Thon, Vojtěch PY - 2009 TI - The evaluation of hypersensitivity to tribenoside (Glyvenol) KW - drug hypersensitivity KW - delayed reaction KW - tribenoside KW - patch test KW - lymphocyte transformation test KW - basophil activation test N2 - Tribenoside is a semisynthetic sugar derivative which is mainly indicated for the treatment of chronic venous insufficiency. Up to 10 % patients treated by tribenoside can suffer from skin side effects. They usually occur as angioedema, urticaria or maculopapular exanthema. We have examined 27 patients with drug eruptions caused by tribenoside during the period from October 2005 to August 2008. Patch tests were performed in 22 patients, lymphocyte transformation tests and basophil activation tests in 8 patients. A positive patch test reaction to tribenoside was seen in 1 patient. Lymphocyte transformation test elicited one border positive reaction and basophil activation test gave a clearly positive reaction in another patient. The results show that both delayed and immediate type of immunologic response may play role in aetiology of the tribenoside induced exanthemas. ER -
ZGAŽAROVÁ, Simona, Hana JEDLIČKOVÁ and Vojtěch THON. The evaluation of hypersensitivity to tribenoside (Glyvenol). In \textit{Book of abstracts na CD - International congress of dermatology. Praha}. 2009.
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