HASOŇ, Stanislav, Vladimír VETTERL, František JELEN and Miroslav FOJTA. Improved sensitivity and selectivity of uric acid voltammetric sensing with mechanically grinded carbon/graphite electrodes. Electrochimica Acta. Amsterdam: Elsevier Science, 2009, vol. 54, No 6, p. 1864-1873. ISSN 0013-4686. |
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@article{873530, author = {Hasoň, Stanislav and Vetterl, Vladimír and Jelen, František and Fojta, Miroslav}, article_location = {Amsterdam}, article_number = {6}, keywords = {Grinded carbon electrodes; Voltammetry; Uric acid; Dopamine; Hypoxanthine; Xanthine; Adenine; Guanine; Purine metabolism; Diagnostics}, language = {eng}, issn = {0013-4686}, journal = {Electrochimica Acta}, title = {Improved sensitivity and selectivity of uric acid voltammetric sensing with mechanically grinded carbon/graphite electrodes}, volume = {54}, year = {2009} }
TY - JOUR ID - 873530 AU - Hasoň, Stanislav - Vetterl, Vladimír - Jelen, František - Fojta, Miroslav PY - 2009 TI - Improved sensitivity and selectivity of uric acid voltammetric sensing with mechanically grinded carbon/graphite electrodes JF - Electrochimica Acta VL - 54 IS - 6 SP - 1864-1873 EP - 1864-1873 PB - Elsevier Science SN - 00134686 KW - Grinded carbon electrodes KW - Voltammetry KW - Uric acid KW - Dopamine KW - Hypoxanthine KW - Xanthine KW - Adenine KW - Guanine KW - Purine metabolism KW - Diagnostics N2 - In this paper we show that a strong enhancement of the UA oxidation signal can be reached by a simple mechanical grinding of the surfaces of glassy carbon or edge plane-oriented pyrolytic graphite electrodes with SiC particles of an optimum size 15 um in contrast to fine polished electrodes. The grinded ones exhibited an excellent separation of oxidation signals of ascorbic acid, dopamine, xanthine and hypoxanthine, making it possible to detect these substances in a mixture. Enhancement of UA and dopamine (DA) oxidation signals at the grinded electrodes allowed their easy detection at nanomolar levels in up to 10e4-fold excesses of ascorbic acid. Due to a strong adsorption at the electrode surface, nanomolar concentrations of UA and DA can be determined by ex situ voltammetry. Similarly strong enhancement of oxidation signals was observed for purine nucleobases, guanine and adenine. The grinded electrodes have been tested in analysis of real clinical samples of human serum or urine. ER -
HASOŇ, Stanislav, Vladimír VETTERL, František JELEN and Miroslav FOJTA. Improved sensitivity and selectivity of uric acid voltammetric sensing with mechanically grinded carbon/graphite electrodes. \textit{Electrochimica Acta}. Amsterdam: Elsevier Science, 2009, vol.~54, No~6, p.~1864-1873. ISSN~0013-4686.
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