SOUCKOVA, E., A. KOVARIK, Ladislav DUŠEK, L. HUMPOLIKOVA-ADAMKOVA, L. LAUEROVA and E. KREJCI. Reduced inducibility of SOCS3 by interferon gamma associates with higher resistance of human breast cancer lines as compared to normal mammary epithelial cells. Neoplasma. 2009, vol. 56, No 5, 8 pp. ISSN 0028-2685.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Reduced inducibility of SOCS3 by interferon gamma associates with higher resistance of human breast cancer lines as compared to normal mammary epithelial cells
Authors SOUCKOVA, E. (203 Czech Republic), A. KOVARIK (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, guarantor), L. HUMPOLIKOVA-ADAMKOVA (203 Czech Republic), L. LAUEROVA (203 Czech Republic) and E. KREJCI (203 Czech Republic).
Edition Neoplasma, 2009, 0028-2685.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30200 3.2 Clinical medicine
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.192
RIV identification code RIV/00216224:14110/09:00040118
Organization unit Faculty of Medicine
UT WoS 000269333200002
Keywords in English suppressor of STAT signaling; STAT1; breast cancer; interferon; cell resistance
Changed by Changed by: prof. RNDr. Ladislav Dušek, Ph.D., učo 670. Changed: 3/3/2010 09:52.
Abstract
The resistance to interferons (IFNs) limits their anticancer therapeutic efficacy. Here we studied the antiproliferative effect of interferon gamma in relation to SOCS3 expression in a panel of breast cancer cell lines and normal mammary epithelial cells. Compared to normal cells most breast cancer lines (7/8) were highly resistant to IFN-gamma.
PrintDisplayed: 25/4/2024 18:42