Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

BLÁHA, Luděk, Pavel BABICA, Klára HILSCHEROVÁ and B. UPHAM. Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins? Toxicon. vol. 55, No 1, p. 126-134. ISSN 0041-0101. doi:10.1016/j.toxicon.2009.07.009. 2010.

Basic information

• Original name: Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?
• Name in Czech: Inhibice GJIC a aktivace MAPK extrakty ze sinic
• Authors: BLÁHA, Luděk (203 Czech Republic, guarantor, belonging to the institution), Pavel BABICA (203 Czech Republic), Klára HILSCHEROVÁ (203 Czech Republic, belonging to the institution) and B. UPHAM (840 United States of America).
• Edition: Toxicon, 2010, 0041-0101.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 30304 Public and environmental health
• Country of publisher: United Kingdom of Great Britain and Northern Ireland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 2.451
• RIV identification code: RIV/00216224:14310/10:00049612
• Organization unit: Faculty of Science
• Doi: http://dx.doi.org/10.1016/j.toxicon.2009.07.009
• UT WoS: 000273921500016
• Keywords (in Czech): GJIC; MAPK; cyanobacteria
• Keywords in English: GJIC; MAPK; cyanobacteria
• Tags: AKb, rivok

Abstract

Extracts of cyanobacteria (laboratory cultures of Microcystis aeruginosa and Aphanizomenon flos-aquae and water blooms dominated by these species) inhibited GJIC and activated MAPKs in a dose-dependent manner (effective concentrations ranging 0.5-5 mg d.w./mL). Effects were independent of the microcystin content and the strongest responses were elicited by the extracts of Aphanizomenon sp.

Abstract (in Czech)

Prokázány efekty extraktů sinic na parametry nádorové promoce, nejsilnější efekty u zástupců Aphanizomenon. Výsledky nesouvisí s obsahem známých toxinů.

Links

• GA524/08/0496, research and development project: Name: Mechanismy nádorové promoce metabolitů toxických sinic

Investor: Czech Science Foundation, Tumor promotional mechanisms of cyanobacterial metabolites

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)