J 2010

Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

BLÁHA, Luděk, Pavel BABICA, Klára HILSCHEROVÁ and B. UPHAM

Basic information

Original name

Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

Name in Czech

Inhibice GJIC a aktivace MAPK extrakty ze sinic

Authors

BLÁHA, Luděk (203 Czech Republic, guarantor, belonging to the institution), Pavel BABICA (203 Czech Republic), Klára HILSCHEROVÁ (203 Czech Republic, belonging to the institution) and B. UPHAM (840 United States of America)

Edition

Toxicon, 2010, 0041-0101

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30304 Public and environmental health

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.451

RIV identification code

RIV/00216224:14310/10:00049612

Organization unit

Faculty of Science

DOI

UT WoS

000273921500016

Keywords (in Czech)

GJIC; MAPK; cyanobacteria

Keywords in English

GJIC; MAPK; cyanobacteria

Tags

Změněno: 20/4/2012 09:33, Ing. Andrea Mikešková

Abstract

ORIG CZ

V originále

Extracts of cyanobacteria (laboratory cultures of Microcystis aeruginosa and Aphanizomenon flos-aquae and water blooms dominated by these species) inhibited GJIC and activated MAPKs in a dose-dependent manner (effective concentrations ranging 0.5-5 mg d.w./mL). Effects were independent of the microcystin content and the strongest responses were elicited by the extracts of Aphanizomenon sp.

In Czech

Prokázány efekty extraktů sinic na parametry nádorové promoce, nejsilnější efekty u zástupců Aphanizomenon. Výsledky nesouvisí s obsahem známých toxinů.

Links

GA524/08/0496, research and development project
Name: Mechanismy nádorové promoce metabolitů toxických sinic
Investor: Czech Science Foundation, Tumor promotional mechanisms of cyanobacterial metabolites
MSM0021622412, plan (intention)
Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)
Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)