DUBOVÝ, Petr, Ilona KLUSÁKOVÁ, Ivana HRADILOVÁ SVÍŽENSKÁ and Václav BRÁZDA. Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain. Histochemistry and Cell Biology. Heidelberg: Springer, 2010, 133/2010, No 3, p. 323-337. ISSN 0948-6143. |
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@article{875339, author = {Dubový, Petr and Klusáková, Ilona and Hradilová Svíženská, Ivana and Brázda, Václav}, article_location = {Heidelberg}, article_number = {3}, keywords = {Chemokine; Satellite glial cells; Chronic constriction injury}, language = {eng}, issn = {0948-6143}, journal = {Histochemistry and Cell Biology}, title = {Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain}, url = {http://www.springerlink.com/content/rn4568715q2833n0/}, volume = {133/2010}, year = {2010} }
TY - JOUR ID - 875339 AU - Dubový, Petr - Klusáková, Ilona - Hradilová Svíženská, Ivana - Brázda, Václav PY - 2010 TI - Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain JF - Histochemistry and Cell Biology VL - 133/2010 IS - 3 SP - 323-337 EP - 323-337 PB - Springer SN - 09486143 KW - Chemokine KW - Satellite glial cells KW - Chronic constriction injury UR - http://www.springerlink.com/content/rn4568715q2833n0/ N2 - There is a growing evidence that chemokines and their receptors play a role in inducing and maintaining neuropathic pain. In the present study, unilateral chronic constriction injury (CCI) of rat sciatic nerve was used to investigate changes for stromal derived factor-1 (SDF1) and its CXCR4 receptor in lumbal and cervical dorsal root ganglia from both sides of naive, operated and sham-operated rats. All operated rats displayed mechanical allodynia and thermal hyperalgesia in hind paws ipsilateral to CCI, but forepaws exhibited only temporal changes of sensitivity. Immunofluorescence staining and Western blot analysis confirmed bilateral alterations of SDF1 and CXCR4 proteins in all examined DRG. No attenuation of mechanical allodynia, but reversed thermal hyperalgesia, in ipsi- and contralateral hind paws was found in CCI-operated rats after i.p. administration of CXCR4 antagonist. These results indicate that SDF1/CXCR4 changes are not limited to DRG associated with injured nerve. ER -
DUBOVÝ, Petr, Ilona KLUSÁKOVÁ, Ivana HRADILOVÁ SVÍŽENSKÁ and Václav BRÁZDA. Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic injury as a model of neuropathic pain. \textit{Histochemistry and Cell Biology}. Heidelberg: Springer, 2010, 133/2010, No~3, p.~323-337. ISSN~0948-6143.
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